中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (36): 6817-6820.doi: 10.3969/j.issn.1673-8225.2011.36.039

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

牙周膜干细胞的研究进展

张  瑛，宋  莉   

  1. 南昌大学第二附属医院，江西省南昌市   330006
  • 收稿日期:2011-03-12 修回日期:2011-05-02 出版日期:2011-09-03 发布日期:2011-09-03
  • 通讯作者: 宋莉，南昌大第二附属医院口腔科，江西省南昌市330006 songli200200@hotmail.com
  • 作者简介:张瑛★，女，1985年生，江西省修水县人，汉族，2011年南昌大学毕业，硕士，主要从事牙周组织工程方向的研究。

The research of periodontal ligament stem cells

Zhang Ying, Song Li   

  1. Second Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Received:2011-03-12 Revised:2011-05-02 Online:2011-09-03 Published:2011-09-03
  • Contact: Song Li, Department of Stomatology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China songli200200@hotmail.com
  • About author:Zhang Ying★, Master, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

PDF

490

被引次数

3

摘要：

背景：从牙周膜组织中分离出的牙周膜干细胞被认为是牙周组织工程的首选种子细胞，有自我更新能力，能分化形成牙周的3种组织：牙槽骨、牙周膜和牙骨质。
目的：就近年来牙周膜干细胞的分离、鉴定、相关细胞因子等方面进行简要综述。
方法：由第一作者检索Pubmed 数据库(http://www.ncbi.nlm.nih.gov/pubmed)、中国知网数据库(http://www. cnki.net/)2004-01/2010-09有关牙周膜干细胞分离、鉴定、相关细胞因子等方面的文献，英文检索词为“periodontal ligament stem cell”，中文检索词为“牙周膜，干细胞”。排除重复性研究，最终纳入35篇文献进行综述。
结果与结论：牙周膜干细胞是一种很有潜力的牙周组织工程种子细胞，能构建组织工程牙周膜，促进牙周缺损的修复。随着研究的深入，影响牙周膜干细胞生物性能的因素逐渐被发现，但其研究还有待进一步完善。

关键词: 牙周膜干细胞, 金属蛋白酶整合素28, 组织工程, 信号分子, 细胞鉴定

Abstract:

BACKGROUND: Periodontal ligament stem cells isolated from periodontal ligament tissue is considered to be the preferred seed cells with self-renewal ability in periodontal tissue engineering and can differentiate to form three kinds of periodontal tissues: alveolar bone, periodontal ligament and cementum.
OBJECTIVE: To review the articles about isolation, identification, and relevant factors of periodontal ligament stem cells in recent years.
METHODS: The first author searched PubMed databases and CKNI database (2004-01/2010-09) for articles regarding isolation, identification, and relevant factors of periodontal ligament stem cells using the keywords of “periodontal ligament stem cells” in English and “periodontal ligament, stem cells” in Chinese. Repetitive articles were excluded, and finally, 35 articles were included.
RESULTS AND CONCLUSION: Periodontal ligament stem cells are a kind of potential seed cells for periodontal tissue engineering, which can reconstruct tissue-engineered periodontal ligament and improve the healing of periodontal defects. Biological properties of periodontal ligament stem cells have been gradually found and their research remains to be further improved.

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