中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (4): 633-636.doi: 10.3969/j.issn.1673-8225.2010.04.014

• 数字化骨科 digital orthopedics • 上一篇    下一篇

噪声与基于解析解自适应网格荧光分子成像重建的关系

汪待发，张  涛，白  净   

  1. 清华大学医学院生物医学工程系，北京市  100084
  • 出版日期:2010-01-22 发布日期:2010-01-22
  • 通讯作者: 白 净，教授，博士生导师，清华大学医学院生物医学工程系，北京市 100084
  • 作者简介:汪待发☆，男，1984年生，博士，主要从事近红外光漫射成像、荧光分子断层成像方面的研究。 wdf@mails.tsinghua.edu.cn
  • 基金资助:

    国家自然科学基金资助项目(30670577，60831003，30930092，30872633) ****；清华-裕元基金资助项目*；国家973计划资助项目(2006CB70570 0) *；国家863计划资助项目(2006 AA020803) *；博士点基金资助项目*

Correlation between noise and fluorescence molecular tomography based on the adaptive-mesh-based algorithm using an analytical solution

Wang Dai-fa, Zhang Tao, Bai Jing   

  1. Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China
  • Online:2010-01-22 Published:2010-01-22
  • Contact: Bai Jing, Professor, Doctoral supervisor, Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China deabj@tsinghua.edu.cn
  • About author:Wang Dai-fa☆, Doctor, Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China wdf@mails.tsinghua.edu.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30670577*, 60831003*, 30930092*, 30872633*; the Tsinghua-Yue-Yuen Medical Science Foundation*; the National Basic Research Program of China (the 973 Program), No. 2006CB705700*; the Hi-Tech Research and Development Program of China (the 863 Program), No. 2006AA020803*; the Special Research Fund for the Doctoral Program of Higher Education of China*

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摘要：

背景：荧光分子断层成像已经成为近年来发展很快的分子影像技术，噪声对这种成像技术提出了挑战。目前噪声对成像结果具体影响的研究还是空白。
目的：利用基于解析解的自适应网格荧光分子断层重建方法，研究信号噪声对重建结果的影响。
方法：在作者之前提出的基于解析解的自适应网格荧光分子断层重建算法的基础上，观察分析了噪声对荧光分子断层成像的影响。
结果与结论：通过在仿真数据中添加噪声，得到了不同信噪比下的重建结果及噪声与重建精度之间关系的规律。实验结果表明，基于解析解的自适应网格荧光分子断层重建算法具有较好的抗噪性。

关键词: 荧光分子断层成像, 图像重建, 自适应网格, 数字化医学, 噪声

Abstract:

BACKGROUND: Fluorescence molecular tomography (FMT) has become a fast developing molecular imaging technique. Noise is a challenge for FMT, and the influence of noise on molecular imaging remains unclear.
OBJECTIVE: To investigate the influence of noise on imaging reconstruction based on the adaptive-mesh-based algorithm using an analytical solution.
METHODS: In this paper, the influence of noise on FMT was studied based on the adaptive-mesh-based algorithm using an analytical solution.
RESULTS AND CONCLUSION: By adding noise to the simulated data, the reconstruction results with different signal-to-noise ratio are obtained and discussed. The experiment results show that the adaptive-mesh-based algorithm is robust in the existence of noise.

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