中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (4): 629-632.doi: 10.3969/j.issn.1673-8225.2010.04.013

• 数字化骨科 digital orthopedics • 上一篇    下一篇

以蒙特卡洛方法建立组织中光剂量数学模型：分析激光对肝组织的损伤

王  旭，李迎新   

  1. 天津医科大学生物医学工程系，天津市  300070
  • 出版日期:2010-01-22 发布日期:2010-01-22
  • 通讯作者: 李迎新，博士，博士生导师，教授，从事激光仪器及激光疗法的研究。 yingxinli2005@yahoo.com.cn
  • 作者简介:王 旭★，男，1983年生，天津市人，汉族，天津医科大学在读硕士，主要从事蒙特卡罗方法研究激光光子和组织的相互作用研究。 winterwxsnow@163.com

Establishment of light dose in tissues mathematical model by Monte Carlo method: Analysis of laser damage to liver tissues

Wang Xu, Li Ying-xin   

  1. Department of Biomedical Engineering, Tianjin Medical University, Tianjin  300070, China　
  • Online:2010-01-22 Published:2010-01-22
  • Contact: Li Ying-xin, Doctor, Doctoral supervisor, Professor, Department of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China yingxinli2005@yahoo.com.cn
  • About author:Wang Xu★, Studying for master’s degree, Department of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China winterwxsnow@163.com

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摘要：

背景：目前很难通过数学分析方法求出或临床直接监测激光能量在生物组织内的传输规律，因此常常采用数值模拟的方法进行预测。用蒙特卡罗方法研究激光光子在组织中的传输，是目前较为理想的研究方法。
目的：采用蒙特卡罗方法建立组织中的光剂量数学模型，探讨激光照射对于肝组织的损伤情况。
方法：采用蒙特卡罗方法，建立不同光学参数下正常组织和肿瘤组织的组织剂量数学模型，逐个计算大量光子迁移轨迹，统计嵌于正常组织和肿瘤组织中的光子宏观能量分布。
结果及结论：通过数学模型得到光损伤随组织深度的增加呈指数衰减的结果，且光子在组织边缘会形成第2个峰值。组织损伤是阈值过程，每条剂量曲线可被视为阈值曲线。采用蒙特卡罗方法模拟激光在肝组织中的传播，得到了激光光子在肝肿瘤组织中的分布规律。结果表明，适量光照强度能引起浅薄全面的肿瘤组织光损伤，深层光损伤伴随正常组织损伤。

关键词: 蒙特卡罗方法, 光子分布, 生物组织, 光损伤, 激光能量传输, 数字化医学

Abstract:

BACKGROUND: Transmitting law of laser in biological tissues is hard to calculate by mathematical analysis or clinical monitoring. Therefore, numerical simulation is commonly used for its prediction. Monte Carlo simulation is an ideal method for this study.
OBJECTIVE: To establish a light dose mathematical model by Monte Carlo method, and to explore the damage of laser to liver tissues.
METHODS: Light dose mathematical models of normal tissues and tumor with varied optical parameters were established by Monte Carlo method, and the migration trajectory of ponderosus photons was calculated one by one, and the distribution of photon was analyzed.
RESULTS AND CONCLUSION: The decay of photo dose with depth was approximately exponential, and the second peak value will be formed at the verge of the organization. The damage of organization was a process of the threshold value. The dose curved shape was the same as the line of threshold. Using Monte Carlo method, the ransmitting law of laser in tissues of liver tumor was obtained. The results demonstrated that optimal ration of illumination intensity can obtain a shallow but entirely selective depth of tumor necrosis, but to obtain deeper tumor necrosis necessarily means some degree of normal tissue damage．

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