中国组织工程研究

中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (29): 4662-4666.doi: 10.3969/j.issn.2095-4344.2779

• 组织构建实验造模 experimental modeling in tissue construction • 上一篇    下一篇

三维数字化测量肾结石的解剖学病因及临床意义

武利兵1，2，许阳阳3，和雨洁2，王海燕2，高  尚2，恩和吉日嘎拉2，李筱贺2，李志军2   

  1. 1北京市房山区良乡医院泌尿外科，北京市  102446；内蒙古医科大学，2基础医学院人体解剖教研室，3研究生院，内蒙古自治区呼和浩特市  010110
  • 收稿日期:2019-09-04 修回日期:2019-09-09 接受日期:2020-03-03 出版日期:2020-10-18 发布日期:2020-09-14
  • 通讯作者: 李筱贺，博士，教授，硕士生导师，内蒙古医科大学基础医学院人体解剖学教研室，内蒙古自治区呼和浩特市 010110 李志军，硕士，教授，博士生导师，内蒙古医科大学基础医学院人体解剖学教研室，内蒙古自治区呼和浩特市 010110
  • 作者简介:武利兵，男，1979年生，内蒙古自治区乌兰察布市人，汉族，主治医师，主要从事泌尿外科临床工作。 许阳阳，男，1991年生，山西省长治市人，汉族，内蒙古医科大学在硕士在读，主要从事数字医学方向研究。
  • 基金资助:
    国家自然科学基金(81460330)；国家自然科学基金(81560348，81860383)；内蒙古教育厅青年科技英才项目(njyt-15-b05)；内蒙古自治区科技计划项目(2016)；内蒙古自治区科技计划项目(2019)；内蒙古自治区科技创新引导项目(2017)；内蒙古自治区自然科学基金(2016ms08131)；内蒙古人社厅归国留学人员基金(TKD2017KJBW012)；内蒙古医科大学科技百万计划基金项目(YKD2017KJBW012)

Anatomical etiology and clinical significance of three-dimensional digital measurement of kidney stones

Wu Libing1, 2, Xu Yangyang3, He Yujie2, Wang Haiyan2, Gao Shang2, Enhejirigala2, Li Xiaohe2, Li Zhijun2   

  1. 1Department of Urinary Surgery, Liangxiang Hospital in Fangshan District, Beijing 102446, China; 2Department of Anatomy, Basic Medical College, 3Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China

  • Received:2019-09-04 Revised:2019-09-09 Accepted:2020-03-03 Online:2020-10-18 Published:2020-09-14
  • Contact: Li Xiaohe, MD, Professor, Master’s supervisor, Department of Anatomy, Basic Medical College, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China Li Zhijun, Master, Professor, Doctoral supervisor, Department of Anatomy, Basic Medical College, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China
  • About author:Wu Libing, Attending physician, Department of Urinary Surgery, Liangxiang Hospital of Fangshan District, Beijing 102446, China; Department of Anatomy, Basic Medical College, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China Xu Yangyang, Master candidate, Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81460330, 81560348 and 81860383; the Youth Science and Technology Talent Project of Inner Mongolia Education Department, No. njyt-15-b05; the Science and Technology Plan Project of Inner Mongolia Autonomous Region, No. 2016 and 2019; the Science and Technology Innovation Leading Project of Inner Mongolia Autonomous Region, No. 2017; the Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2016ms08131; Returned Scholars Fund of Inner Mongolia Human Resources and Social Security Agency, No. TKD2017KJBW012; the Science and Technology Million Plan of Inner Mongolia Medical University, No. YKD2017KJBW012

PDF

111

摘要：

文题释义：

肾结石：是泌尿系统最常见的疾病，与饮食中的钙含量和酸性物质增高有关，严重者常需要进行手术治疗，肾结石手术几乎占了泌尿外科手术数量的一半。

三维数字化：利用医学工程软件把人体脏器的实体模型进行虚拟创建，之后进行修改、模拟、设计等一些操作。

背景：肾结石发生病因有很多，但对于肾脏解剖形态学研究是否影响结石的产生还未有明确答案。

目的：重建肾脏的三维立体模型；测量与肾结石病因的相关解剖结构数据进行分析。

方法：随机选取2017年12月至2019年2月在北京房山区良乡医院就诊的30例肾结石患者作为肾结石组，对照组是同期进行体检的正常人30例。两组受试者采集肾脏CT的扫描数据后，利用Mimics 16.0.软件通过图像分割和融合来重建肾脏的三维立体模型；测量肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离；并对肾结石患者肾脏解剖学指标进行多参数Logistics回归分析。

结果与结论：①肾结石患者与正常人的肾在肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离方面的三维数字化测量结果差异无统计学意义(P > 0.05)。②肾结石患者肾脏解剖学多参数Logistics回归分析结果表明，肾结石患者的肾脏长度、肾脏宽度、肾窦长径、肾窦宽径、肾盂与输尿管连接处直径、肾上缘至棘突纵线距离、肾下缘至棘突纵线距离、肾门至棘突纵线距离等与肾结石的形成无明显相关性(P > 0.05)。提示肾脏形态学的不同与结石形成无关。

ORCID: 0000-0001-6850-7615(武利兵)；0000-0001-5877-8358(许阳阳)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 肾结石, 数字化测量, 三维重建, 解剖学病因

Abstract:

BACKGROUND: There are many causes of kidney stones, but there is no clear answer to whether kidney

anatomy and morphology studies affect the generation of stones.

OBJECTIVE: To reconstruct a three-dimensional model of the kidney and to measure and analyze anatomical data related to the etiology of kidney stones.

METHODS: Thirty patients with kidney stones treated at Liangxiang Hospital in Fangshan District, Beijing from December 2017 to February 2019 were randomly selected as the study group, and the control group was 30 normal people who underwent physical examination during the same period. After collecting renal CT scan data from two groups of patients, the three-dimensional model of the kidney was reconstructed by image segmentation and fusion using Mimics 16.0. The length and width of the kidney, the length and width of the renal sinus, diameter of the junction between the renal pelvis and ureter, the distance from the upper edge of the kidney to the longitudinal line of the spinous process, the distance from the lower edge of the kidney to the longitudinal line of the spinous process, and the distance from the hilum to the longitudinal line of the spinous process. Multi-parameter Logistic regression analysis was performed on kidney anatomy parameters of patients with kidney stones.

RESULTS AND CONCLUSION: There were no significant differences in the three-dimensional digital measurement results between patients with kidney stones and healthy people in the following aspects: the length and width of the kidney, length and width of the renal sinus, diameter of the junction between the renal pelvis and ureter, distance from the upper edge of the kidney to the longitudinal line of the spinous process, distance from the lower edge of the kidney to the longitudinal line of the spinous process, and distance from the hilum to the longitudinal line of the spinous process (P > 0.05). Multi-parameter Logistic regression analysis results of the kidney of patients with kidney stones indicated that there was no significant correlation among the length and width of the kidney, length and width of the renal sinus, diameter of the junction between the renal pelvis and ureter, distance from the upper edge of the kidney to the longitudinal line of the spinous process, distance from the lower edge of the kidney to the longitudinal line of the spinous process, and distance from the hilum to the longitudinal line of the spinous process (P > 0.05). These findings reveal that the difference in kidney morphology has nothing to do with the formation of stones.

Key words: kidney stones, digital measurement, three-dimensional reconstruction, anatomical etiology

中图分类号: