中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (8): 1241-1247.doi: 10.3969/j.issn.2095-4344.1086

• 骨与关节综述 bone and joint review • 上一篇    下一篇

磁共振弥散张量成像技术在临床疾病诊治过程中更多的优势和价值

刘建航1,刘 昊1,陈道云2,徐志为1,谢桂鑫1,李锦威3   

  1. 1广西中医药大学附属瑞康医院正骨推拿科,广西壮族自治区南宁市 530011;2临武县中医院骨伤科,湖南省郴州市 424300;3香港邕康堂中医馆,中国香港特别行政区  999077
  • 出版日期:2019-03-18 发布日期:2019-03-18
  • 通讯作者: 刘昊,广西中医药大学在读硕士,广西中医药大学附属瑞康医院正骨推拿科,广西壮族自治区南宁市 530011
  • 作者简介:刘建航,男,1976年生,广西壮族自治区桂林市人,汉族,2013年南方医科大学毕业,博士,主任医师,教授。
  • 基金资助:

    国家自然科学基金(81760796),项目负责人:陈跃平;广西科学研究与技术开发计划课题(桂科攻1598012-34),项目负责人:刘建航;广西医疗卫生适宜技术开发与推广应用项目(S2017054),项目负责人:刘建航;广西青年智库研究会(GXQNZKA-1702),项目负责人:刘建航

Advantages and values of magnetic resonance diffusion tensor imaging in clinical diagnosis and treatment   

Liu Jianhang1, Liu Hao1, Chen Daoyun2, Xu Zhiwei1, Xie Guixin1, Li Jinwei3   

  1. 1Department of Orthopedic Manipulation, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China; 2Department of Orthopedics, Linwu County Hospital of Traditional Chinese Medicine, Chenzhou 424300, Hunan Province, China; 3Yown Kang Tong Chinese Medical Centre, Hong Kong Special Administrative Region 999077, China
  • Online:2019-03-18 Published:2019-03-18
  • Contact: Liu Hao, Master candidate, Department of Orthopedic Manipulation, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • About author:Liu Jianhang, MD, Chief physician, Professor, Department of Orthopedic Manipulation, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81760796 (to CYP); the Program of Guangxi Scientific Research and Technology Development, No. 1598012-34 (to LJH); the Development, Popularization and Application of Appropriate Medical Technology of Guangxi Zhuang Autonomous Region, No. S2017054 (LJH); the Youth Zhiku Research Association, No. GXQNZKA-1702 (to LJH)

摘要:

文章快速阅读:

 

文题释义:
核磁共振弥散张量成像技术:是核磁共振成像的一种特殊形式,是在磁共振扩散加权成像基础上发展、深化而成的另一种成像与后处理技术。
扩散加权成像的成像原理:就是以水分子的自由扩散为基础,单方向施加敏感梯度磁场,利用其在不同介质中扩散的差异性而成像,而弥散张量成像则是在一个三维空间对水分子的扩散进行分析,则需在空间坐标轴的多个方向上施加敏感梯度磁场来实现,而其成像原理在每个方向上与扩散加权成像原理相同。
 
摘要
背景:磁共振弥散张量成像技术是一项新兴的磁共振成像方法,由于其利用水分子在组织中自由扩散的原理揭示组织病变特点,常被用于检测神经系统细微结构的改变以及评价神经系统疾病的预后。
目的:综述磁共振弥散张量成像技术的特征及临床应用的作用。
方法:第一作者以“弥散张量成像、各向异性参数、表观弥散系数、纤维示踪、白质、脑血管、脊髓、肌肉、椎间盘”为中文检索词,以“diffusion tensor imaging,DTI,FA,ADC,fibre tracing,DTT,white matter,cerebrovascular diseases,spinal cord,muscle,intervertebral disc”为英文检索词,检索中国期刊全文数据库、ELSEVIER数据库、EMBASE数据库、Springer数据库、IEEE、Wiley Online Library、Google Scholar和PubMed数据库中关于磁共振弥散张量成像技术的研究与应用的文章,共纳入41篇文献。
结果与结论:弥散张量成像技术是一项尚待继续开发的功能性磁共振成像技术,通过计算组织内水分子自由扩散特征参数值,反映其扩散能力,继而能较准确地显示组织内部微观结构的表现,目前弥散张量成像技术应用的领域较为广泛,比如脊髓病变,阿尔茨海默病、癫痫及脑肿瘤等中枢神经系统疾病,周围神经损伤,脑梗死等脑血管疾病,椎间盘退变,肌肉系统病变等方面,但技术开发程度还有很大空间,未来弥散张量成像技术在肌肉纤维示踪、组织损伤评估等方面的研究尚有很大前景,有望成为颈椎病、腰椎间盘突出症等退行性疾病的无创性评价肌肉损伤的间接特征性的重要技术指标,从而为临床早期诊断和治疗肌肉结构改变提供有力的帮助。

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程
ORCID: 0000-0002-8263-7683(刘建航)

关键词: 弥散张量成像, 扩散加权成像, 各向异性参数, 表观弥散系数, 平均扩散率, 轴向扩散率, 径向扩散率, 纤维示踪

Abstract:

BACKGROUND: Diffusion tensor imaging is a new method of magnetic resonance. Because it utilizes the principle of free diffusion of water molecules in tissues to reveal the characteristics of tissue lesions, it is often used to detect changes in the subtle structure of the nervous system and to evaluate the prognosis of neurological diseases.

OBJECTIVE: To review the characteristics and clinical application of magnetic resonance diffusion tensor imaging.
METHODS: The keywords were “diffusion tensor imaging, DTI, FA, ADC, fiber tracing, DTT, white matter, cerebral vascular, spinal cord, muscle, intervertebral disc” in Chinese and English, respectively. Articles relevant about the research and application of magnetic resonance diffusion tensor imaging were search in CNKI, ELSEVIER, EMBASE, Springer, IEEE, Wiley Online Library, Google Scholar and PubMed Databases. Totally 41 eligible articles were included.
RESULTS AND CONCLUSION: Diffusion tensor imaging is a functional magnetic resonance imaging technique, which should be developed. By calculating the characteristic parameters of free diffusion of water molecules in the tissue, it can reflect the diffusion ability, and then it is able to show the microstructure of the tissue accurately. Diffusion tensor imaging technology is widely used in a wide range of areas, for example, spinal cord diseases, Alzheimer’s disease, epilepsy, brain tumors and other central nervous system diseases, peripheral nerve injury, cerebral infarction and other cerebrovascular diseases, intervertebral disc degeneration, and muscular system diseases. However, there is still a lot of space for technical development, and diffusion tensor imaging technology in the future in the tracing of muscle fibers, tissue damage assessment and other aspects still has great prospects. It is expected to become an important technical indicator in noninvasive evaluation of the indirect characteristics of muscle injury in degenerative diseases, such as, cervical spondylosis and lumbar disc herniation, so as to provide a powerful help for early clinical diagnosis and treatment of muscle structural changes.

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程

Key words: Tissue Engineering, Diffusion Tensor Imaging, Spinal Cord, Peripheral Nerves

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