中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (16): 2489-2495.doi: 10.3969/j.issn.2095-4344.0819

• 软骨组织构建 cartilage tissue construction • 上一篇    下一篇

工程化软骨几何形状对缺损修复区力学行为的影响

赵永政1,2,刘海英1,2,张春秋1,2,胡亚辉1,2   

  1. 1天津市先进机电系统设计与智能控制重点实验室,天津市  300384;2机电工程国家级实验教学示范中心(天津理工大学),天津市  300384
  • 收稿日期:2017-11-15 出版日期:2018-06-08 发布日期:2018-06-08
  • 通讯作者: 刘海英,博士,讲师,天津市先进机电系统设计与智能控制重点实验室,天津市 300384;机电工程国家级实验教学示范中心(天津理工大学),天津市 300384
  • 作者简介:赵永政,男,1991年生,河南省驻马店市人,汉族,天津理工大学在读硕士,主要从事生物力学的研究。
  • 基金资助:

    国家自然科学基金青年基金资助项目(11402172);国家自然科学基金重点资助项目(11432016);天津市自然科学重点基金(15JCZJC32800)

Geometric shapes of tissue-engineered cartilage exert effects on mechanical behaviors of a defected area

Zhao Yong-zheng1, 2, Liu Hai-ying1, 2, Zhang Chun-qiu1, 2, Hu Ya-hui1, 2   

  1. 1Tianjin Key Laboratory of Advanced Mechatronic System Design and Intelligent Control, Tianjin 300384, China; 2National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology), Tianjin 300384, China
  • Received:2017-11-15 Online:2018-06-08 Published:2018-06-08
  • Contact: Liu Hai-ying, M.D., Lecturer, Tianjin Key Laboratory of Advanced Mechatronic System Design and Intelligent Control, Tianjin 300384, China; National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology), Tianjin 300384, China
  • About author:Zhao Yong-zheng, Studying for master’s degree, Tianjin Key Laboratory of Advanced Mechatronic System Design and Intelligent Control, Tianjin 300384, China; National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology), Tianjin 300384, China
  • Supported by:

    the National Natural Science Foundation of China for the Youth, No. 11402172; the Key Project of National Natural Science Foundation of China, No. 11432016; the Natural Science Foundation of Tianjin, No. 15JCZJC32800

摘要:

文章快速阅读:

文题释义:
数值模拟:也叫计算机模拟。依靠电子计算机,结合有限元或有限容积的概念,通过数值计算和图像显示的方法,达到对工程问题和物理问题乃至自然界各类问题研究的目的。
三维模型:①通常用计算机或者其它视频设备进行显示物体的多边形表示,显示的物体可以是现实世界的实体,也可以是虚构的物体;②任何物理自然界存在的东西都可以用三维模型表示;③三维模型经常用三维建模工具这种专门的软件生成,但是也可以用其它方法生成;④作为点和其它信息集合的数据,三维模型可以手工生成,也可以按照一定的算法生成;⑤尽管通常按照虚拟的方式存在于计算机或者计算机文件中,但是在纸上描述的类似模型也可以认为是三维模型。
摘要
背景:
关节软骨损伤修复结果的不确定性与修复区的力学行为有关,缺损修复的形状、层深及载荷特性均不同程度地改变修复区的力学环境。
目的:通过有限元仿真分析在生理载荷作用下关节软骨缺损修复区的力学行为。
方法:应用有限元软件ABAQUS建立基于横观各向同性的关节软骨损伤与修复的轴对称模型。分析在压缩载荷作用下,软骨不同修复形状(圆柱、圆台、正棱柱、椭圆柱形)和深度对缺损软骨修复区力学行为的影响。
结果与结论:①模拟结果表明,不同形状、层深的工程化软骨对软骨修复区力学行为影响规律不同;②中间层缺损修复时应力集中现象最显著,深(全)层缺损修复时应力分布较合理;③圆柱形工程化软骨修复时的应力场及液相流场分布规律与无损软骨最为接近;临床上,可以选用圆柱形或圆台形工程化软骨进行修复,且尽量避免中间层修复。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-4888-3338(赵永政)

关键词: 工程化软骨, 横观各向同性, 软骨缺损, 修复, 数值模拟, 力学行为, 组织构建

Abstract:

BACKGROUND: Uncertainty of repairing articular cartilage defects is highly associated with the mechanical behaviors of the defected area, and the mechanical environment varies with the defect shape, depth and load.
OBJECTIVE: To study the mechanical behaviors of articular cartilage defects under physiological load by finite element analysis.
METHODS: The axisymmetric model of articular cartilage injury and repair based on transversely isotropy was established using ABAQUS software. The mechanical behaviors of the defect zone repaired with different repair shapes (cylindrical, frustum of a cone, orthorhombic prism, elliptical column) and depths of tissue-engineered cartilage under compressive load were analyzed.
RESULTS AND CONCLUSION: The simulation results showed that there were significant differences in the mechanical behaviors of the defect area repaired with tissue-engineered cartilage in different shapes and depths. The stress concentration was the most obvious at the middle-layer defect repair, and the stress distribution was more reasonable at the deep (whole) layer defect repair. Furthermore, the distribution of the stress field and the liquid flow field at the cylinder-shaped tissue-engineered cartilage repair was the closest to the normal cartilage. That is to say, the tissue-engineered cartilage in cylinder or frustum-cone shape is recommended to repair cartilage defect. Importantly, the middle-layer repair is inadvisable.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Cartilage, Numerical Analysis, Computer-Assisted, Stress, Mechanical, Tissue Engineering

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