中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (29): 5497-5500.doi: 10.3969/j.issn.1673-8225.2011.29.044

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

自体唇黏膜移植修补羟基磷灰石义眼座植入后的眼座暴露

张晓辉，王建明，王  峰   

  1. 西安交通大学医学院第二附属医院眼科，陕西省西安市  710004
  • 收稿日期:2011-01-18 修回日期:2011-02-05 出版日期:2011-07-16 发布日期:2011-07-16
  • 作者简介:张晓辉☆，男，1973年生，陕西省西安市人，汉族，西安交通大学在读博士，主治医师，主要从事角膜病，青光眼，眼前段研究。 tonyzxh0324@163.com

Autologous buccal mucosal transplantation for repair of orbital implant exposure after hydroxyapatite orbital implantation

Zhang Xiao-hui, Wang Jian-ming, Wang Feng   

  1. Department of Ophthalmology，Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an   710004, Shaanxi Province, China
  • Received:2011-01-18 Revised:2011-02-05 Online:2011-07-16 Published:2011-07-16
  • About author:Zhang Xiao-hui☆，Studying for doctorate, Attending physician, Department of Ophthalmology，Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China tonyzxh0324@163.com

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379

被引次数

1

摘要：

背景：修补羟基磷灰石义眼座暴露的移植物很多，包括异体巩膜、羊膜、口腔黏膜和游离皮瓣。其中自体口腔唇黏膜属于黏膜组织，具有一定的黏液分泌功能，上皮细胞增生速度快，修复好，同时自体唇黏膜不会发生移植排斥反应。
目的：观察自体唇黏膜移植修补羟基磷灰石义眼座植入后眼座暴露的效果。
方法：2006-01/2010-10羟基磷灰石义眼座植入后出现眼座暴露11例(11只眼)，男6例，女5例。年龄41~67岁，平均年龄54岁。5例行单纯自体唇黏膜修补，6例取出眼座，进行自体唇黏膜移植+结膜囊成形。移植后观察唇黏膜存活情况，结膜囊深度，睑裂高度和外观。
结果与结论：随访1~12个月唇黏膜生存良好，与球结膜融合。结膜囊大小深度正常，双侧睑裂高度基本对称，外观满意，11例患者均无羟基磷灰石再暴露并发症发生。结果显示采用自体唇黏膜移植可以有效修复羟基磷灰石义眼座植入后眼座暴露，能较好地满足患者外观需求。

关键词: 自体唇黏膜移植, 羟基磷灰石义眼座植入, 眼座暴露, 结膜囊成形, 生物相容性

Abstract:

BACKGROUND: As for orbital implant exposure, repaired implants include heterologous sclera, amnion, oral mucosa, and separated skin flap. But homologous oral mucosa belongs to mucous tissue, which has mucus secretion function to some degree. Epithelial cell has rapid proliferation and good repair. Additionally, autologous buccal mucosal transplantation cannot suffer rejection.
OBJECTIVE: To investigate the effect of autologous buccal mucosal transplantation for repair of orbital implant exposure after hydroxyapatite (HA) orbital implantation.
METHODS: Totally 11 cases (11 eyes) orbital implant exposure occurred after HA orbital implantation between January 2006 and October 2010, 6 males and 5 females, aged 41-67, mean age of 54 years. Five cases treated with simple autologous buccal mucosal patch-up, 6 cases with autologous buccal mucosal transplantation + conjunctival sac formation after orbital removal. Survival condition of buccal mucosa, conjunctival sac depth, palpebral fissure highness and facial appearance were observed after transplantation.
RESULTS AND CONCLUSION: After 1-12 months followed-up, buccal mucosal membrane grew up well and fused with eyeball conjunctiva. Depth of conjunctival sac was normal and binocular palpebral fissure elevated basically symmetry and satisfactory appearance. Eleven patients had no HA re-exposure complications. The results show that autologous buccal mucosal transplantation can effectively repair orbital implant exposure after HA orbital implantation, and also satisfy patients’ esthetic need.

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