中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (3): 543-546.doi: 10.3969/j.issn.1673-8225.2011.03.040

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程技术及生物材料修复运动性关节软骨损伤

马金玉1，薛  媛2，杨洪武2   

  1. 1齐齐哈尔大学体育学院，黑龙江省齐齐哈尔市   161006
    2秦皇岛职业技术学院体育部，河北省秦皇岛市  066100
  • 收稿日期:2010-10-14 修回日期:2010-12-01 出版日期:2011-01-15 发布日期:2011-01-15
  • 作者简介:马金玉，女，1953年生，黑龙江省齐齐哈尔市人，汉族，1974年齐齐哈尔大学体育学院毕业，副教授，主要从事体育教学与运动训练方面的研究。 capslock889@163.com

Tissue engineering technology and biomaterials for repair of sports articular cartilage injury

Ma Jin-yu1, Xue Yuan2, Yang Hong-wu2   

  1. 1Physical Education College of Qiqihar University, Qiqihar  161006, Heilongjiang Province, China
    2Physical Education College of Qinhuangdao Vocational College, Qinhuangdao  066100, Hebei Province, China
  • Received:2010-10-14 Revised:2010-12-01 Online:2011-01-15 Published:2011-01-15
  • About author:Ma Jin-yu, Associate professor, Physical Education College of Qiqihar University, Qiqihar 161006, Heilongjiang Province, China capslock889@163.com

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446

被引次数

4

摘要：

目的：总结组织工程技术及生物材料在防治运动性关节软骨损伤中的应用特点。
方法：以“关节软骨，组织工程技术，生物材料”为中文关键词，以“tissue enginneering, articular cartilage, scaffold material”为英文关键词，采用计算机检索Pubmed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及维普数据库(http://www.cqvip.com/)1993-01/2010-10的相关文章，排除重复研究或Meta分析类文章。以23篇文献为主，重点对修复运动性关节软骨损伤种子细胞、支架材料、细胞因子及其性能进行讨论。
结果：计算机初检得到104篇文献，根据纳入排除标准，对组织工程软骨的种子细胞、生物支架材料以及用于组织工程中的细胞因子进行总结与分析。种子细胞是制约组织工程软骨进一步临床应用的首要因素，目前常采用的种子细胞有软骨细胞、骨髓基质干细胞和胚胎干细胞等；生物支架材料包括天然材料和人工合成可降解聚合物等；用于软骨组织工程的生长因子主要包括转化生长因子、骨形成蛋白、成纤维细胞生长因子、胰岛素样生长因子等。
结论：迄今为止，无论是工程软骨的种子细胞、支架材料、培养环境等还没有任何一种材料被认为最理想，寻求一种具有良好性能的组织工程化关节软骨是未来研究的重点。但目前很多研究仍处于实验阶段，还有一些问题有待于解决，特别是组织工程细胞支架材料植入体内后，材料的降解与细胞功能发挥是否同步，会不会产生遗传物质改变、基因表达或基因突变等问题，将其应用于临床更需要相关学者专家不断的实践和探索。

关键词: 关节软骨, 组织工程, 生物材料, 种子细胞, 细胞因子

Abstract:

OBJECTIVE: To summarize the application characteristics of tissue engineering technology and biomaterials in preventing sports articular cartilage injury.
METHODS: A computer-based online search of Pubmed database (http://www.ncbi.nlm.nih.gov/PubMed) and VIP database (http://www.cqvip.com/) from January 1993 to October 2010 was performed for related articles, using “articular cartilage, tissue engineering technology, biomaterials” for the Chinese key words and “tissue engineering, articular cartilage, scaffold material” for the English key words, duplicated research or Meta analysis were eliminated. Twenty-three papers mainly discuss seed cells, scaffolds, cytokines and their properties in the repair of sports articular cartilage injury.
RESULTS: Totally 104 studies were screened out by computer search, according to inclusion and exclusion criteria, studies regarding the seed cells and bio-scaffolds for cartilage tissue engineering, as well as cytokines for tissue engineering were summarized and analyzed. Seed cells are the primary factor restricting clinical application of tissue engineered cartilage, the common seed cells include cartilage cells, bone marrow stromal stem cells and embryonic stem cells; bio-scaffold materials includes natural materials and synthetic biodegradable polymers; the growth factors for cartilage tissue engineering include transforming growth factor, bone morphogenetic protein, fibroblast growth factor, insulin-like growth factor and so on.
CONCLUSION: So far, there is no ideal materials for the seed cells and scaffold materials of engineered cartilage, as well as culture environment, the focus of future research is a kind of tissue engineered articular cartilage with good performance. However, many studies are still in the experimental stage, and some problems need to be solved, especially after tissue engineering scaffolds are implanted, whether the material degradation is synchronized with cell functioning, thus altering genetic materials, gene expression or gene mutation, their clinical application requires relevant scholars and experts to constantly practice and explore.

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