中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (32): 6040-6043.doi: 10.3969/j.issn.1673-8225.2010.32.033

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

自体骨髓干细胞血管腔内移植治疗糖尿病下肢动脉闭塞症

张会峰1，赵志刚1，白卫星2   

  1. 1河南省人民医院二内老年医学部内分泌科，河南省郑州市  450003；2河南省人民医院介入科，河南省郑州市  450003
  • 出版日期:2010-08-06 发布日期:2010-08-06
  • 作者简介:张会峰☆，男，1973年生，河南省汝南县人，汉族，在读博士，主要从事糖尿病及其并发症的研究。 zhf666777@163.com
  • 基金资助:

    河南省卫生厅普通科技攻关项目(200803103)。

Zhang Hui-feng1, Zhao Zhi-gang1, Bai Wei-xing2   

  1. 1 Second Department of Endocrinology, Geriatric Medicine Branch, Henan Provincial People’s Hospital, Zhengzhou  450003, Henan Province, China; 2 Department of Intervention, Henan Provincial People’s Hospital, Zhengzhou  450003, Henan Province, China
  • Online:2010-08-06 Published:2010-08-06
  • About author:Zhang Hui-feng☆, Studying for doctorate, Second Department of Endocrinology, Geriatric Medicine Branch, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China zhf666777@163.com
  • Supported by:

     the Common Science and Technology Project of Health Department of Henan Province. No.200803103*

PDF

405

被引次数

9

摘要：

背景：自体骨髓干细胞通过肌肉注射移植治疗肢体缺血的疗效在动物实验和临床上均得到证实。近年来，小球囊扩张是治疗糖尿病下肢动脉闭塞症的常见方法。然而，通过导管注入自体骨髓干细胞这种干细胞移植和介入治疗结合方式在临床上常见于治疗冠心病，而鲜见于下肢动脉闭塞症的治疗。
目的：多指标客观评估自体骨髓干细胞血管腔内移植治疗糖尿病下肢动脉闭塞症的临床效果。
方法：选择2007-06/2009-06河南省人民医院老年医学部内分泌科收治的糖尿病下肢动脉闭塞症患者51例，男27例，女24例，随机分为两组：实验组：接受小球囊扩张和血管腔内自体骨髓干细胞移植治疗。对照组：仅接受小球囊扩张治疗。移植前后两组患者疼痛、冷感、间歇性跛行及移植后踝肱指数的变化、及并发症发生情况。
结果与结论：移植2周后，实验组患者下肢疼痛症状、冷感、间歇性跛行明显缓解率、好转率、无效率均高于对照组(P < 0.01)。踝肱指数变化差异亦有显著性意义(P < 0.01)。所有患者未出现并发症和不良反应。提示自体骨髓干细胞血管腔内移植治疗糖尿病下肢动脉闭塞症是一种简便、安全、有效的治疗方法。

Abstract:

BACKGROUND: Intramuscular injection transplantation of autologous bone marrow stem cells for the treatment of limb ischemia has obtained good outcomes, which have been confirmed by animal test and clinic. Recently, small balloon dilatation is a common method to treat diabetic lower limb arteriosclerosis. However, stem cell transplantation and interventional therapy by catheter infusion of autologous bone marrow stem cells are commonly used to treat coronary artery disease, but seldom used for treating arterial occlusion of the lower limb.
OBJECTIVE: To evaluate the clinical efficacy of transplantation of autologous bone marrow stem cells for the treatment of diabetic lower limb arterial occlusion.
METHODS: From June 2007 to June 2009, a total of 51 patients with diabetic lower limb arterial occlusion (27 males and 24 females) were enrolled at the Department of Endocrinology, Geriatric Medicine Branch, Henan Provincial People’s Hospital, and randomly divided two groups. Patients in the experimental group underwent small balloon dilatation and autologous bone marrow stem cells transplantation. Patients in the control group received small balloon dilatation. Pain, cold feeling, intermittent claudication before and after transplantation were observed, as well as ankle brachial index changes and complications following transplantation were observed.
RESULTS AND CONCLUSION: At 2 week posttransplantation, remission rate, improvement rate and inefficiency of lower-limb pain symptom, cold feeling and intermittent claudication were significantly greater in the experimental group compared with the control group (P < 0.01). There were significant differences in ankle-brachial index changes (P < 0.01). No complication or adverse effects were observed. Results suggest that transplantation of autologous bone marrow stem cells through balloon dilatation might be a simple, safe and effective method for diabetic lower limb arterial occlusion.

中图分类号: