中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (32): 6036-6039.doi: 10.3969/j.issn.1673-8225.2010.32.032

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

肌源干细胞注射治疗压力性尿失禁的研究进展

涂由兵，李爱斌   

  1. 武汉大学人民医院生殖中心，湖北省武汉市   430060
  • 出版日期:2010-08-06 发布日期:2010-08-06
  • 通讯作者: 李爱斌，博士，硕士生导师，主任医师，教授，武汉大学人民医院生殖中心，湖北省武汉市 430060 liaibin67@163. com
  • 作者简介:涂由兵★，男，1983年生，湖北省孝感市人，汉族，2010年武汉大学人民医院毕业，硕士，主要从事女性压力性尿失禁的治疗研究。 tybing83@163. com
  • 基金资助:

    国家自然科学基金资助项目(30870638)，湖北省自然基金项目(2006ABA223)。

Research progress addressing muscle-derived stem cells injection for treatment of stress urinary incontinence

Tu You-bing, Li Ai-bin   

  1. Department of Reproductive Center, Renmin Hospital, Wuhan University, Wuhan  430060, Hubei Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Li Ai-bin, Doctor, Master’s supervisor, Chief physician, Professor, Department of Reproductive Center, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China liaibin67@163.com
  • About author:Tu You-bing★, Master, Department of Reproductive Center, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China tybing83@163.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30870638*; the Natural Science Foundation of Hubei Province, No. 2006ABA223*

PDF

408

被引次数

3

摘要：

背景：注射疗法治疗压力性尿失禁是一种微创的治疗手段，但是由于既往注射材料的限制，可出现各种并发症，远期疗效差，寻找新的注射材料具有重大意义。
目的：对压力性尿失禁应用肌源性干细胞治疗的研究进行回顾分析。
方法：由第一作者检索2003/2010 PubMed数据库、Springer数据库及中国知网数据库关于肌源性干细胞用于压力性尿失禁治疗研究方面的文献，英文检索词为“stress urinary incontinence, muscle-derived stem cell”，中文检索词为“压力性尿失禁，肌源干细胞”，排除重复性研究，计算机初检得到40篇文献，根据纳入标准保留24篇进一步归纳总结。
结果与结论：压力性尿失禁的治疗方式主要包括非手术治疗和手术治疗，其中手术治疗存在多种并发症甚至出现矫枉过正的风险，而注射疗法作为一种非手术治疗方式，具有操作简便，患者可接受性更高。肌源性干细胞注射后可在体内长期存活，并具有不被分解、不易迁移、低免疫原性的优点，在注射治疗压力性尿失禁方面具有广阔的前景。

关键词: 压力性尿失禁, 肌源干细胞, 注射, 疗效, 综述文献

Abstract:

BACKGROUND: Injection therapy for stress urinary incontinence is a minimally invasive means of treatment, but because of previous vaccination materials restriction, there are many complications, with poor long-term effects. It is significant to search new injection materials.
OBJECTIVE: To retrospectively analyze the research of stress urinary incontinence using muscle-derived stem cells.
METHODS: The first author retrieved PubMed database, Springer database and China National Knowledge Infrastructure for articles concerning muscle-derived stem cells for treatment of stress urinary incontinence published from 2003 to 2010. The key words were “stress urinary incontinence, muscle-derived stem cell”. A total of 40 articles were retrieved primarily by computer, and 24 articles were finally included for review according to inclusion criteria.
RESULTS AND CONCLUSION: Treatment method of stress urinary incontinence mainly included non-surgery therapy and surgery therapy. The surgery treatment exists many complications, even risk for overcorrect. However, the injection therapy, as a non-surgery therapy, was simple to operate, could be accepted by patients. Muscle-derived stem cells following injection have many advantages, such as long-term survival, not easy to broken down, not easy to move, low immunogenicity, and will have a bright prospect in the future.

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