中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5325-5328.doi: 10.3969/j.issn.1673-8225.2010.29.002

• 抗菌抗病毒材料 antibacterial and antiviral materials • 上一篇    下一篇

密闭性敷料支架的制备及其性能

唐  娜1，蔡文智2，邓  凌3，李淑娟1，汪晓娟1，李  超1   

  1. 1深圳市第四人民医院，广东省深圳市518033；2南方医科大学护理学院，广东省广州市  510515；3南方医科大学南方医院，广东省广州市 510515
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 作者简介:唐 娜★，女，1977年生，安徽省淮南市人，回族，南方医科大学在读硕士，主管护师，主要从事临床护理的研究。 prettymedictn@yahoo.com.cn
  • 基金资助:

    广东省自然科学基金项目(2004B30101019)。

Preparation and property of closed dressing intelligent scaffolds

Tang Na1, Cai Wen-zhi2, Deng Ling3, Li Shu-juan1, Wang Xiao-juan1, Li Chao1   

  1. 1 Shenzhen Fourth People’s Hospital, Shenzhen   518033, Guangdong Province, China; 2 Nursing College of Southern Medical University, Guangzhou  510515; Guangdong Province, China; 3 Nanfang Hospital, Southern Medical University, Guangzhou   510515, Guangdong Province, China
  • Online:2010-07-16 Published:2010-07-16
  • About author: Tang Na★, Studying for master’s degree, Nurse-in-charge, Shenzhen Fourth People’s Hospital, Shenzhen 518033, Guangdong Province, China prettymedictn@yahoo.com.cn
  • Supported by:

    Guangdong Provincial Natural Science Foundation, No. 2004B30101019*

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摘要：

背景：近年来创伤敷料的研究发展较快，但很少有中药联合高分子材料制备的复合密闭敷料，且现有的创伤敷料作用较局限，不能适用于任何创伤伤口。
目的：制备适用于中药载入的密闭敷料支架，并测定其性能。
方法：将壳聚糖、明胶、聚乙烯醇，壳聚糖、明胶、聚乙烯醇和海藻酸钠分别在一定条件下共混，预冻，冷冻干燥得到支架，考察两支架的吸水性、含水量、相对保湿性、透气性、孔隙率、支架的外形。
结果与结论：壳聚糖、明胶、聚乙烯醇所制成支架的吸水性、含水量、相对保湿性、孔隙率优于壳聚糖、明胶、聚乙烯醇和海藻酸钠所制成的支架，两组比较差异有显著性意义(P < 0.05)。说明壳聚糖、明胶、聚乙烯醇适宜作为密闭敷料支架材料。

关键词: 敷料支架, 壳聚糖, 明胶, 海藻酸钠, 聚乙烯醇

Abstract:

BACKGROUND: In recent years, the wound dressing research has developed quickly, but few reports the closed dressings prepared by traditional Chinese medicine combined with polymer composite, the efficacy of existing wound dressings is limited and not suitable for all wounds.
OBJECTIVE: To prepare closed dressing scaffolds loading traditional Chinese medicine, and to determine their properties.
METHODS: Firstly the chitosan, gelatin and polyvinyl alcohol were mixed, while the above materials were additionally mixed with sodium alginate. The scaffolds were prepared by mixing, precooling and freeze drying. The properties of the enclosed dressing scaffolds was evaluated by water absorption, moisture content, relative moisture retention, permeability, porosity, and scaffold appearance.
RESULTS AND CONCLUSION: Water absorption, moisture content, relative moisture retention and porosity of the mixture of chitosan, gelatin and polyvinyl alcohol were significantly better than those of the mixture containing chitosan, gelatin, polyvinyl alcohol and sodium alginate (P < 0.05). Chitosan, gelatin and polyvinyl alcohol are suitable to be used as closed dressing intelligent scaffolds.

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