中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (26): 4831-4835.doi: 10.3969/j.issn.1673-8225.2010.26.020

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

血氧水平依赖功能磁共振成像对单指被动运动任务激活脑区分布的评价

陈志光1，黄穗乔2，刘 波1，钟镜联2，叶瑞心2，许晓矛2   

  1. 1广东省中医院放射科，广州    510000；
    2中山大学附属第二医院放射科MR室，广东省广州市    510120
  • 出版日期:2010-06-25 发布日期:2010-06-25
  • 通讯作者: 黄穗乔，博士，主任医师，中山大学第二附属医院放射科MR室，广东省广州市 510120 huang_sq2@ yahoo.com.cn
  • 作者简介:陈志光，男，1980年生，广东省深圳市人，汉族，2007年中山大学附属第二医院毕业，硕士，医师，主要从事中枢神经系统疾病的影像学诊断及脑部功能磁共振成像研究。 t2flair@163.com
  • 基金资助:

    广东省科技计划项目(2003C30614)

Brain activation distribution following passive finger movement: A blood oxygenation level dependent functional magnetic resonance imaging evaluation

Chen Zhi-guang1, Huang Sui-qiao2, Liu Bo1, Zhong Jing-lian2, Ye Rui-xin2, Xu Xiao-mao2   

  1. 1Department of Radiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou  510000, Guangdong Province, China;
    2MR Room, Department of Radiology, Second Hospital of Sun Yat-sen University, Guangzhou  510120, Guangdong Province, China
  • Online:2010-06-25 Published:2010-06-25
  • Contact: Huang Sui-qiao, MR Room, Department of Radiology, Second Hospital of Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China huang_sq2@yahoo. com.cn
  • About author:Chen Zhi-guang, Master, Physician, Department of Radiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510000, Guangdong Province, China t2flair@163.com
  • Supported by:

    the Science and Technology Development Program of Guangdong Province, China, No. 2003C30614*

PDF

344

被引次数

3

摘要：

背景：运动功能在脑皮质的功能映射是至今为止被研究得最多的课题之一，但既往对运动功能的绝大部分研究均采用主动运动任务，因而不可避免主动运动所带来的各种误差以及研究对象的局限性。被动运动显然可以解决以上困难以及误差，但是否可代替主动运动进行功能成像，现尚未有定论。
目的：通过比较右手食指主动与被动运动所激活脑区分布的差异，探讨以被动运动代替主动运动进行血氧水平依赖功能磁共振成像的可行性。
方法：分别采用被动及主动运动任务对8名健康志愿者进行血氧水平依赖功能磁共振成像。功能资料经过转换格式后，运用脑功能分析软件SPM2进行离线分析。通过比较健康受试者被动运动与主动运动的个体脑激活区、组内平均激活区的异同点，并对功能资料进行基于体素的组内、组间比较，验证以被动运动任务代替主动运动任务的可行性。另根据SPM2输出的时间－信号强度动态曲线，计算信号上升百分率，分析主、被动运动任务所引起的脑区激活程度的差异。
结果与结论：食指被动运动与主动运动比较，对侧大脑半球主要感觉运动区的激活区出现率均为100%，主、被动任务主要感觉运动区的激活区体积差异无显著性意义，辅助运动区、运动前区的出现率相近；被动运动与运动各活化区的激活曲线比较，两组资料间信号上升百分率的差异无显著性意义。提示被动运动可代替主动运动进行血氧水平依赖功能磁共振成像。

关键词: 被动运动, 主动运动, 血氧水平依赖脑功能成像, SPM2, 术前评估

Abstract:

BACKGROUND: Motor function in cerebral cortex functional mapping has been extensively explored, but the majority of previous studies utilized active exercise tasks, which result in various errors and limitations to subjects. Passive movement can solve the above problems, but it remains unclear whether passive movement can replace active movement for functional imaging.
OBJECTIVE: By comparing the brain functional localization variance between active right-handed finger movement and passive finger movement, to explore the feasibility of passive movement replacing active movement to perform blood oxygenation level dependent functional MRI (BOLD-fMRI).
METHODS: A total of 8 normal volunteers were selected for BOLD-fMRI with both passive and active finger movements using Philips Intera Gyroscan 1.5T superconducting MR scanner. The fMRI data format was transformed and postprocessed by SPM2, a brain functional analyzing tool. By comparing the results of brain activation area and mean imaging between the two tasks, and analyzing the data using t test in SPM2, the feasibility of substitution with passive finger movement was verified. In addition, on the basis of time-signal intensity dynamic curve output automatically by SPM2, the signal increasing rate percent (SIRP) and the scale difference of brain activation in the two tasks were computed and analyzed.
RESULTS AND CONCLUSION: The rates of appearances of SM1 activation from the contra-lateral hemisphere were 100%, and SM1 activation volumes were not statistically significant in both two tasks. The appearances of SMA, PMC activation were close, and the SIRPs were not statistically significant. BOLD-fMRI imaging can be performed by passive finger movement to substitute active finger movement.

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