中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (13): 2445-2448.doi: 10.3969/j.issn.1673-8225.2010.13.041

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

冠状动脉支架置入后的血小板活化及其生物相容性

多丽娟   

  1. 营口经济技术开发区中心医院干诊科，辽宁省营口市 115007
  • 出版日期:2010-03-26 发布日期:2010-03-26
  • 作者简介:多丽娟，女，1967年生，辽宁省人，苗族，哈尔滨医科大学医疗系毕业，主治医师，主要从事心血管内科方面的研究。

Platelet activation and biocompatibility following coronary artery stent implantation

Duo Li-juan   

  1. Department of Cadres, Yingkou Development Zone Center Hospital, Yingkou   115007, Liaoning Province, China
  • Online:2010-03-26 Published:2010-03-26
  • About author:Duo Li-juan, Attending physician, Department of Cadres, Yingkou Development Zone Center Hospital, Yingkou 115007, Liaoning Province, China

PDF

438

被引次数

7

摘要：

目的：评价冠状动脉支架置入后的生物相容性，探讨冠状动脉支架置入后血小板活化与支架再狭窄的关系。
方法：用计算机检索中国期刊全文数据库(1990/2009)和Pubmed数据库(1990/2009)，以“冠状动脉支架，血小板活化，生物相容性”或“coronary artery stent, platelet activation, biocompatibility”为检索词进行检索。纳入主题内容与冠状动脉支架置入后的生物相容性以及支架置入后血小板活化与支架再狭窄关系联系紧密的文章；排除Meta分析及重复性研究。
结果：冠状动脉支架置入后损伤血管壁从而激活机体的免疫应答过程。内皮细胞、血小板和炎性白细胞释放的生长因子及细胞因子，最终促使血管平滑肌细胞增殖是导致再狭窄的根本原因。文章研究了冠状动脉支架置入后血小板活化与支架再狭窄的关系及其各种冠状动脉支架置入后的生物相容性评价，并展望了生物可降解支架的发展前景。
结论：生物可降解支架不仅能够将再狭窄的可能性降至最小，而且提供了对抗血栓的保护作用，这些都为支架置入后血管再狭窄问题的解决带来了新的希望。

关键词: 冠状动脉支架, 血小板活化, 生物相容性, 心血管植入物, 再狭窄

Abstract:

OBJECTIVE:To evaluate the biocompatibility of coronary artery stent implantation and explore the relationship between platelet activation and stent restenosis following coronary artery stent implantation.
METHODS: A computer-based online search of CNKI (1990/2009) and Pubmed database(1990/2009) was performed with the key words “coronary artery stent, platelet activation, biocompatibility” in Chinese and English. Articles related to biocompatibility and relationship between platelet activation and stent restenosis following coronary artery stent implantation were included. Meta analysis and repetitive studies were excluded.
RESULTS:Coronary artery stent implantation damages vessel wall and activates body immune response process. Growth factors and cytokines released from endothelial cells, platelet and inflammatory leukocyte promotes vascular smooth muscle cell proliferation, which contributes to restenosis. This study explored the relationship of platelet activation and in-stent restenosis and biocompatibility following stenting and prospected development of biodegradable stents.
CONCLUSION: Biodegradable stents could minimize possibility of restenosis, and protect from thrombosis, which bring hope for treating restenosis following stent implantation.on.

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