中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (8): 1437-1441.doi: 10.3969/j.issn.1673-8225.2010.08.026

• 生物材料综述 biomaterial review • 上一篇    下一篇

牙周局部缓释型制剂的研究现状及应用进展

王  聃，邓嘉胤   

  1. 天津医科大学口腔医院牙周科，天津市  300070
  • 出版日期:2010-02-19 发布日期:2010-02-19
  • 通讯作者: 邓嘉胤，副教授，天津医科大学口腔医院牙周科，天津市 300070
  • 作者简介:王 聃★，女，1986年生，山东省济宁市金乡县人，汉族，天津医科大学在读硕士，主要从事牙周病学研究。 wdyz2000@163.com

Research status and application progression in periodontal locally sustained-release antimicrobials

Wang Dan, Deng Jia-yin   

  1. Department of Periodontics, Hospital of Stomatology, Tianjin Medical University, Tianjin   300070, China
  • Online:2010-02-19 Published:2010-02-19
  • Contact: Deng Jia-yin, Associate professor, Department of Periodontics, Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China
  • About author:Wang Dan★, Studying for master’s degree, Department of Periodontics, Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China wdyz2000@163.com

PDF

615

被引次数

41

摘要：

背景：局部应用缓释剂辅助治疗牙周病是近年来牙周药物治疗研究中的一个活跃领域，其中剂型、药物和载体材料方面的研究都有了很大进展。
目的：对国内外应用牙周局部缓释剂的现状及新进展作一综述。
方法：应用计算机检索CNKI和Pubmed数据库中1999-01/2009-10关于牙周局部缓释剂的文章，在标题和摘要中以“牙周炎，治疗，药物，缓释”或“periodontitis，treatment，medications, sustained-release”为检索词进行检索。选择内容与牙周局部缓释剂有关的文章，同一领域则选择近期发表或发表在权威杂志文章。初检得到143篇文献，根据纳入标准选择40篇文献进行综述。
结果与结论：牙周局部缓释剂的应用对临床上一些特殊牙周炎的治疗起到了很好的辅助作用，其以用药量小、作用时间长、靶向作用好等特点被广泛关注，尤其随着复合药物和牙周组织再生研究的发展，牙周局部缓释剂在临床治疗中的应用必将更加广泛。

关键词: 牙周炎, 药物治疗, 局部缓释剂, 牙周与口腔组织再生修复材料, 综述文献

Abstract:

BACKGROUND: Local application of sustained-release antimicrobials serve as an adjuvant therapy of periodontitis, and the dosage form, medicine and carrier material have greatly developed.
OBJECTIVE: To summarize the current situation and progression of periodontal local sustained-release antimicrobials at home and abroad.
METHODS: A computer-based online search of CNKI and Pubmed (1999-01/2009-10) was performed for the related articles about sustained-release antimicrobials, with the key words “periodontitis, treatment, medication, and sustained-release”. The articles in the same field published recently or in authoritative journals were selected. A total of 143 articles were collected, and 40 related sustained-release antimicrobials were included.
RESULTS AND CONCLUSION: Application of sustained-release antimicrobials is a well adjuvant therapy for some special clinical periodontitis. It is widely used due to its low dosage, long lasting-time and well target effect. The clinical application of sustained-release antimicrobials is promising along with the development of compound medicine and periodontal tissue regeneration.

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