中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (26): 6729-6735.doi: 10.12307/2026.837

• 功能性生物材料Functional biomaterials • 上一篇    下一篇

β-磷酸三钙/聚乙烯醇及羟基磷灰石/聚乙烯醇骨替代材料的制备与性能表征

胡志钊1，2，3，刘照永1，郭  静1，金圣男1，周琦琪2，3，胡  杨2，3   

  1. 1珠海市人民医院(北京理工大学附属医院，暨南大学珠海临床医学院)口腔科，广东省珠海市  519000；2新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科，新疆维吾尔自治区乌鲁木齐市  830054；3新疆维吾尔自治区口腔医学研究所，新疆维吾尔自治区乌鲁木齐市  830054
  • 接受日期:2026-01-06 出版日期:2026-09-18 发布日期:2026-03-10
  • 通讯作者: 胡杨，硕士，副教授，副主任医师，新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科，新疆维吾尔自治区乌鲁木齐市 830054；新疆维吾尔自治区口腔医学研究所，新疆维吾尔自治区乌鲁木齐市 830054
  • 作者简介:胡志钊，男，1998年生，湖南省郴州市人，瑶族，硕士，主治医师，主要从事口腔修复种植学、口腔材料学、组织工程学方面的研究。
  • 基金资助:
    新疆维吾尔自治区重点研发任务专项项目(2016B03049-2)，项目负责人：胡杨；新疆维吾尔自治区自然科学基金项目(2022D01C752)，项目负责人：周琦琪

Preparation and characterization of beta-tricalcium phosphate/polyvinyl alcohol and hydroxyapatite/polyvinyl alcohol bone substitute materials

Hu Zhizhao1, 2, 3, Liu Zhaoyong1, Guo Jing1, Jin Shengnan1, Zhou Qiqi2, 3, Hu Yang2, 3   

  1. 1Department of Stomatology, Zhuhai People's Hospital (Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China; 2Department of Oral Restoration and Implants, First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi 830054, Xinjiang Uygur Autonomous Region, China; 3Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Accepted:2026-01-06 Online:2026-09-18 Published:2026-03-10
  • Contact: Hu Yang, MS, Associate professor, Associate chief physician, Department of Oral Restoration and Implants, First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi 830054, Xinjiang Uygur Autonomous Region, China; Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • About author:Hu Zhizhao, MS, Attending physician, Department of Stomatology, Zhuhai People's Hospital (Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China; Department of Oral Restoration and Implants, First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi 830054, Xinjiang Uygur Autonomous Region, China; Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Supported by:
    Key Research and Development Task Special Project of Xinjiang Uygur Autonomous Region, No. 2016B03049-2 (to HY); Natural Science Foundation Project of Xinjiang Uygur Autonomous Region, No. 2022D01C752 (to ZQQ)

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摘要：
文题释义：
β-磷酸三钙：是一种生物活性陶瓷材料，主要成分包括钙和磷，具有良好的生物相容性和生物降解性。β-磷酸三钙可与骨组织结合和降解，促进骨细胞的生长和再生，作为骨填充材料和植入物在骨科、牙科修复和再生领域的应用前景广阔。
羟基磷灰石：具有良好的生物相容性，是人体骨骼的主要无机成分，可释放钙和磷等矿物离子参与人体钙磷代谢，对于牙周及骨组织修复领域有重要研究价值。
聚乙烯醇：是一种水溶性聚合物，具有良好的生物相容性、黏固性和降解性，可作为新型纳米材料或药物载体应用在牙周及骨组织修复领域。

背景：现阶段，口腔牙周骨替代材料多存在生物力学性能和降解性不佳的缺点，采用复合牙周骨替代材料可以弥补单一材料的不足，更好地实现“牙周骨组织工程体”的构建。
目的：采用冷冻干燥法制备β-磷酸三钙/聚乙烯醇与羟基磷灰石/聚乙烯醇复合材料，表征复合材料的性能。 
方法：制备浓度为15%的聚乙烯醇水凝胶，将不同质量的β-磷酸三钙分别加入聚乙烯醇水凝胶中，冷冻干燥后得到10%，20%，30%β-磷酸三钙/聚乙烯醇复合材料；将不同质量的羟基磷灰石分别加入聚乙烯醇水凝胶中，冷冻干燥后得到10%，20%，30%羟基磷灰石/聚乙烯醇复合材料。采用扫描电镜、X射线能量色散谱仪器、X射线衍射仪、X射线光电子能谱技术、拉曼光谱对各组复合材料的性能进行表征。
结果与结论：①扫描电镜和X射线能量色散谱仪分析结果显示，β-磷酸三钙和羟基磷灰石颗粒已成功与聚乙烯醇水凝胶形成了稳定的复合材料，随着β-磷酸三钙或羟基磷灰石浓度的增加，β-磷酸三钙/聚乙烯醇和羟基磷灰石/聚乙烯醇复合材料颗粒的聚集程度增加、孔隙减小，各组复合材料的主要元素包括Ca、P、C和O。②X射线光电子能谱技术、X 射线衍射仪、拉曼光谱结果显示，β-磷酸三钙/聚乙烯醇组与羟基磷灰石/聚乙烯醇组复合材料并未出现新的弯曲振动峰、伸缩振动峰、特征峰等。提示采用冷冻干燥法制备的β-磷酸三钙/聚乙烯醇与羟基磷灰石/聚乙烯醇复合材料性能稳定。
https://orcid.org/0009-0000-8450-2224(胡志钊)
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: β-磷酸三钙, 羟基磷灰石, 聚乙烯醇, 牙周骨替代材料, 性能表征, 生物力学

Abstract: BACKGROUND: Currently, many oral periodontal bone substitute materials suffer from drawbacks such as poor biomechanical properties and degradation characteristics. Using composite periodontal bone substitute materials can compensate for the shortcomings of single materials and better facilitate the construction of "periodontal bone tissue engineering constructs."
OBJECTIVE: To prepare β-tricalcium phosphate/polyvinyl alcohol and hydroxyapatite/polyvinyl alcohol composite materials using freeze-drying method and characterize their properties.
METHODS: A 15% polyvinyl alcohol hydrogel was prepared. Different amounts of β-tricalcium phosphate were added to the polyvinyl alcohol hydrogel. After freeze-drying, 10%, 20%, and 30% β-tricalcium phosphate/polyvinyl alcohol composite materials were obtained. Similarly, different amounts of hydroxyapatite were added to the polyvinyl alcohol hydrogel, and after freeze-drying, 10%, 20%, and 30% hydroxyapatite/polyvinyl alcohol composite materials were obtained. The properties of each group of composite materials were characterized using scanning electron microscopy, X-ray energy dispersive spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Raman spectroscopy.
RESULTS AND CONCLUSION: (1) Scanning electron microscopy and X-ray energy dispersive spectroscopy analysis showed that β-tricalcium phosphate and hydroxyapatite particles successfully formed stable composite materials with the polyvinyl alcohol hydrogel. With increasing concentrations of β-tricalcium phosphate or hydroxyapatite, the aggregation of β-tricalcium phosphate/polyvinyl alcohol and hydroxyapatite/polyvinyl alcohol composite material particles increased, and the porosity decreased. The main elements in each group of composite materials included Ca, P, C, and O. (2) X-ray photoelectron spectroscopy, X-ray diffraction, and Raman spectroscopy results showed that no new bending vibration peaks, stretching vibration peaks, or characteristic peaks appeared in the β-tricalcium phosphate/polyvinyl alcohol and hydroxyapatite/polyvinyl alcohol composite materials. It is indicated that the β-tricalcium phosphate/polyvinyl alcohol and hydroxyapatite/polyvinyl alcohol composite materials prepared by freeze-drying method exhibited stable properties.


Key words: β-tricalcium phosphate, hydroxyapatite, polyvinyl alcohol, periodontal bone substitute material, performance characterization, biomechanics

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