中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (21): 5573-5581.doi: 10.12307/2026.774

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

人体手舟骨显微形态学特征的Micro CT成像技术分析

张德洲1，吕  远1，2，李  琨3，4，陈  杰3，杨向荣5，赵海龙4，张少杰3，4，马  渊4，郝韵腾4，杨  洋3，高明杰3，王志强3，李志军3，4，史  君6，王  星3，4   

  1. 1内蒙古医科大学研究生院，内蒙古自治区呼和浩特市  010110；2包头市肿瘤医院微创肿瘤介入外科，内蒙古自治区包头市  014030；内蒙古医科大学基础医学院，3解剖学教研室，6生理学教研室，内蒙古自治区呼和浩特市  010110；4内蒙古医科大学基础医学院数字医学中心/内蒙古自治区数字转化医学工程技术研究中心，内蒙古自治区呼和浩特市  010059；5内蒙古医科大学第一临床医学院，内蒙古自治区呼和浩特市  010030
  • 接受日期:2025-08-08 出版日期:2026-07-28 发布日期:2026-03-05
  • 通讯作者: 王星，博士，副教授，内蒙古医科大学基础医学院解剖学教研室，内蒙古自治区呼和浩特市 010110；内蒙古医科大学基础医学院数字医学中心/内蒙古自治区数字转化医学工程技术研究中心，内蒙古自治区呼和浩特市 010059 并列通讯作者：史君，副教授，内蒙古医科大学基础医学院生理学教研室，内蒙古自治区呼和浩特市 010110
  • 作者简介:张德洲，男，1998年生，贵州省铜仁市人，土家族，内蒙古医科大学在读硕士，主要从事脊柱与脊髓的数字化研究。 并列第一作者：吕远，男，1981年生，内蒙古自治区包头市人，内蒙古医科大学在读硕士，主要从事肿瘤介入研究。
  • 基金资助:
    内蒙古自治区高等学校青年科技英才支持计划资助(NJYT22009)，项目负责人：王星；内蒙古医科大学科研重点项目(YKD2021ZD011)，项目负责人：王星；内蒙古自治区卫生健康委医疗卫生科技计划项目(202201217)，项目负责人：王星；内蒙古医科大学博士启动基金项目(YKD2023BSQD014)，项目负责人：王星；内蒙古医科大学教学创新团队(NYCXTD202406)，项目负责人：王星；内蒙古医科大学2024年度“善学”人才(ZY20242104)，项目负责人：王星；内蒙古医科大学2025年大学生科技创新“英才培育”项目(YCPY2025002)，项目负责人：杨向荣

Micromorphological characteristics of human scaphoid bone based on Micro CT imaging technology

Zhang Dezhou1, Lyu Yuan1, 2, Li Kun3, 4, Chen Jie3, Yang Xiangrong5, Zhao Hailong4, Zhang Shaojie3, 4, Ma Yuan4, Hao Yunteng4, Yang Yang3, Gao Mingjie3, Wang Zhiqiang3, Li Zhijun3, 4, Shi Jun6, Wang Xing3, 4   

  1. 1Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; 2Minimally Invasive Tumor Interventional Surgery, Baotou Cancer Hospital, Baotou 014030, Inner Mongolia Autonomous Region, China; 3Human Anatomy Teaching and Research Section, 6Physiology Teaching and Research Section, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; 4Digital Medicine Center, School of Basic Medicine, Inner Mongolia Medical University/Inner Mongolia Autonomous Region Digital Translational Medicine Engineering Technology Research Center, Hohhot 010059, Inner Mongolia Autonomous Region, China; 5First Clinical Medical School, Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China 

  • Accepted:2025-08-08 Online:2026-07-28 Published:2026-03-05
  • Contact: Wang Xing, PhD, Associate professor, Human Anatomy Teaching and Research Section, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Digital Medicine Center, School of Basic Medicine, Inner Mongolia Medical University/Inner Mongolia Autonomous Region Digital Translational Medicine Engineering Technology Research Center, Hohhot 010059, Inner Mongolia Autonomous Region, China Co-corresponding author: Shi Jun, Associate professor, Physiology Teaching and Research Section, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China
  • About author:Zhang Dezhou, MS candidate, Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China Lyu Yuan, MS candidate, Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Minimally Invasive Tumor Interventional Surgery, Baotou Cancer Hospital, Baotou 014030, Inner Mongolia Autonomous Region, China Zhang Dezhou and Lyu Yuan contributed equally to this article.
  • Supported by:
    Program for Young Scientists and Technologists in Higher Education Institutions of Inner Mongolia Autonomous Region, No. NJYT22009 (to WX); Key Project of Scientific Research of Inner Mongolia Medical University, No. YKD2021ZD011 (to WX); Medical and Health Science and Technology Program of Inner Mongolia Autonomous Region Health and Health Commission, No. 202201217 (to WX); Doctoral Starting Fund project of Inner Mongolia Medical University, No. YKD2023BSQD014 (to WX); Teaching Innovation Team of Inner Mongolia Medical University, No. NYCXTD202406 (to WX); 2024 Annual “Good at Learning” Talent of Inner Mongolia Medical University, No. ZY20242104 (to WX); 2025 College Students' Scientific and Technological Innovation “Talent Cultivation” Project of Inner Mongolia Medical University, No. YCPY2025002 (to YXR)

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摘要：

文题释义：

手舟骨：又称腕舟状骨，古称高骨、龙骨，属于腕骨，是近排腕骨中最长最大的一块，呈长弧形，其状如舟，很不规则，其远端超过远排腕骨，平头状骨的腰部，其腰部相当于两排腕间骨关节面的平面，分为结节、腰部和体部3部分。
Micro CT：又称微型CT，是一种基于X射线的高分辨率三维成像技术，能够以非破坏性方式对微小样本内部结构进行亚微米级精度的可视化分析。

摘要
背景：临床上，由于手舟骨的特殊解剖特点和内部骨小梁分布特征等往往使得骨折的治疗效果普遍不佳，常导致骨折不愈合和缺血性坏死，进而引发腕关节炎和功能丧失。
目的：利用Micro CT技术对手舟骨标本进行扫描，分析其内部显微结构特征，测量各区域骨小梁显微结构参数值，以发现手舟骨骨小梁的区域差异，旨在为手舟骨骨折的预防、治疗及骨折机制研究提供科学依据。
方法：选取5具成人尸体标本的双侧手舟骨(10例)进行Micro CT扫描，通过对手舟骨3个感兴趣区域(结节部、腰部、体部)内骨小梁的勾选与重建，详细观察手舟骨内部的显微形态特征，测量和比较各区域骨小梁显微结构参数值的差异。
结果与结论：①Micro CT图像显示手舟骨表面皮质骨相对较薄，内部充满复杂的骨小梁微观结构；靠近皮质骨的板层状骨小梁相对密集，向内部延伸成杆状骨小梁；从矢状面、冠状面和横断面上观察，腰部内骨小梁分布较为稀疏，而体部和结节部内骨小梁分布则更为致密；②手舟骨结节部的骨体积分数、骨表面积、骨表面积组织体积比、骨小梁分离度、骨小梁数目、骨小梁连通性、骨小梁连接密度、分形维数、骨矿物质密度和骨矿物质含量在左右侧别间比较差异均有显著性意义(P < 0.05)；腰部和体部的各骨小梁显微结构参数值在左右侧别间比较差异均无显著性意义(P > 0.05)；③手舟骨的骨体积、骨体积分数、骨表面积、骨表面积组织体积比、骨表面积骨体积比、骨矿物质密度和骨矿物质含量在体部与结节部、腰部之间比较差异有显著性意义(P < 0.05)；手舟骨的骨小梁厚度在体部与结节部之间比较差异有显著性意义(P < 0.05)；手舟骨的骨小梁分离度、分形维数在体部与结节部、腰部，结节部与腰部之间差异有显著性意义(P < 0.05)；手舟骨的骨小梁数目、骨小梁连通性、骨小梁连接密度在腰部与结节部、体部之间比较差异有显著性意义(P < 0.05)；手舟骨的组织体积、各向异性程度在体部、结节部、腰部之间比较差异均无显著性意义(P > 0.05)；④结果显示，手舟骨的骨小梁显微结构参数值存在区域性差异，其中腰部的骨密度和强度较低，是最容易发生骨折的部位，该发现从骨小梁微观结构角度为理解手舟骨骨折机制提供了理论依据；同时，此次研究揭示的手舟骨不同部位的骨小梁结构特征也为设计针对性的内固定器械提供了理论依据。


中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: ">手舟骨, Micro CT, 显微形态, 骨小梁, 区域差异, 骨小梁显微结构

Abstract: BACKGROUND: Clinically, the unique anatomical characteristics and internal trabecular distribution of the scaphoid bone often result in poor fracture treatment outcomes, often leading to nonunion and avascular necrosis of the fracture, which in turn causes wrist arthritis and functional loss.
OBJECTIVE: To analyze the internal microstructural characteristics of scaphoid bone specimens using Micro CT technology and measure the microstructural parameters of trabeculae in each region to identify regional differences in scaphoid trabeculae and provide a scientific basis for the prevention, treatment, and fracture mechanism research of scaphoid fractures.
METHODS: Bilateral scaphoid bones from five adult cadaveric specimens (10 cases) were scanned with Micro CT. Trabeculae within three regions of interest (tuberosity, waist, and body) were selected and reconstructed to examine the microscopic morphology of the scaphoid bone in detail. The differences in trabecular microstructural parameters were measured and compared within each region.
RESULTS AND CONCLUSION: (1) Micro CT images showed that the cortical bone on the surface of the scaphoid bone was relatively thin, while the interior was filled with complex trabecular microstructures. The lamellar trabeculae near the cortical bone were relatively dense, extending into rod-shaped trabeculae inward. Observations from sagittal, coronal, and transverse planes showed that the trabeculae were sparsely distributed in the waist, while they were densely distributed in the body and tuberosity. (2) The bone volume, bone surface, bone surface/total volume, trabecular separation, trabecular number, connectivity, connection density, fractal dimension, bone mineral density, and bone mineral content of the scaphoid bone were significantly different between the left and right sides (P < 0.05). There were no significant differences in the trabecular microstructural parameters of the waist and body between the left and right sides (P > 0.05). (3) The bone volume, bone volume fraction, bone surface, bone surface/total tissue volume, bone surface/total bone volume, bone mineral density, and bone mineral content of the scaphoid bone were significantly different between the body and the tuberosity, as well as the waist (P < 0.05); the trabecular thickness of the scaphoid bone was significantly different between the body and the tuberosity, as well as the waist (P < 0.05); the trabecular separation and fractal dimension of the scaphoid bone were significantly different between the body and the tuberosity, as well as the waist, and between the tuberosity and the waist (P < 0.05). The trabecular number, connectivity, and connection density of the scaphoid bone were significantly different between the waist and the tuberosity, as well as the body (P < 0.05). There were no significant differences in the tissue volume and anisotropy of the scaphoid bone between the body, tuberosity, and waist (P > 0.05). (4) The results showed that there were regional differences in the values of trabecular microstructural parameters of the scaphoid bone. The lumbar region had lower bone density and strength and was the most prone to fracture. This finding provides a theoretical basis for understanding the mechanism of scaphoid fracture from the perspective of trabecular microstructure. Furthermore, the trabecular structural characteristics of different parts of the scaphoid bone revealed in this study also provide a theoretical basis for the design of targeted internal fixation devices.

Key words: ">scaphoid bone, micro CT, microscopic morphology, trabecular bone, regional differences, bone trabecular microstructure

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