中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (12): 3066-3074.doi: 10.12307/2026.667

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    下一篇

经颅直流电刺激即刻和3周后上肢运动功能及脑功能分析

侯  兵1，赵鸿斐2，车鹏程1，王梓祎1，高  赞1，陈琳渝1，王金芝1，窦  娜1   

  1. 1华北理工大学护理与康复学院，河北省唐山市  063210；2山东省淄博市中心医院康复医学科，山东省淄博市  255000
  • 收稿日期:2025-03-14 接受日期:2025-08-09 出版日期:2026-04-28 发布日期:2025-09-29
  • 通讯作者: 窦娜，硕士，副教授，华北理工大学护理与康复学院，河北省唐山市 063210
  • 作者简介:侯兵，女，2000年生，天津市人，汉族，华北理工大学在读硕士，初级康复治疗师，主要从事神经康复研究。
  • 基金资助:
    河北省2024年度医学科学研究课题(20240161)，项目负责人：窦娜；河北省康复工程与再生医学重点实验室(SZX202327)，项目负责人：车鹏程；河北省“机器人+”应用“揭榜挂帅”项目，项目负责人：车鹏程

Analysis of upper limb motor function and brain function immediately and 3 weeks after transcranial direct current stimulation

Hou Bing1, Zhao Hongfei2, Che Pengcheng1, Wang Ziyi1, Gao Zan1, Chen Linyu1, Wang Jinzhi1, Dou Na1   

  1. Hou Bing1, Zhao Hongfei2, Che Pengcheng1, Wang Ziyi1, Gao Zan1, Chen Linyu1, Wang Jinzhi1, Dou Na1
    1School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063210, Hubei Province, China; 2Department of Rehabilitation Medicine, Zibo Central Hospital, Zibo 255000, Shandong Province, China
  • Received:2025-03-14 Accepted:2025-08-09 Online:2026-04-28 Published:2025-09-29
  • Contact: Dou Na, MS, Associate professor, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063210, Hubei Province, China ​
  • About author:Hou Bing, MS candidate, Primary rehabilitation therapist, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063210, Hubei Province, China
  • Supported by:
    2024 Hebei Province Medical Science Research Project, No. 20240161 (to DN); Hebei Province Key Laboratory of Rehabilitation Engineering and Regenerative Medicine, No. SZX202327 (to CPC); Hebei Province “Robotics +” Application Leading Project (to CPC)

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摘要：


文题释义：
经颅直流电刺激：是一种非侵入性脑皮质刺激技术，通过电极在头皮施加低强度直流电调节大脑皮质的活动，具有安全、无创和无痛的特点。
脑卒中后上肢功能障碍：指在发生脑卒中或脑血管意外后，由于脑部病变导致上肢在运动控制、感觉、协调等方面出现功能异常。

背景：脑卒中后由于脑神经功能缺损会进一步导致患者上肢运动功能障碍，而脑功能和上肢运动功能恢复对改善日常生活活动能力具有重要作用。尽管已有研究探讨了单次经颅直流电刺激即刻对脑卒中患者脑电活动的影响，但针对短期疗程经颅直流电刺激的治疗效果仍需进一步深入探究。
目的：评估脑卒中患者经颅直流电刺激即刻和3周后的上肢运动功能及脑功能。
方法：招募30例缺血性脑卒中偏瘫患者，随机分为试验组(n=15)和对照组(n=15)。试验组在常规康复治疗基础上接受双极经颅直流电刺激，而对照组接受伪经颅直流电刺激，治疗周期为3周。在干预前、首次干预后和干预3周后进行Fugl-Meyer评定量表上肢部分评分、Wolf运动功能测试评分及静息态脑电图评估。
结果与结论：①对照组干预后即刻与干预前相比无显著变化，而试验组干预后即刻Fugl-Meyer评定量表上肢部分评分较干预前提高(P < 0.05)；②与干预前相比，两组患者干预3周后Fugl-Meyer评定量表上肢部分评分、Wolf运动功能测试评分提高及脑电频带变化明显改善(P < 0.05)，试验组改善的效果更明显；③相关性分析显示，试验组干预前后Fugl-Meyer评定量表上肢部分评分差值及Wolf运动功能测试评分差值与δ全脑平均功率呈负相关关系(r=-0.716，r=-0.546)，与α全脑平均功率呈正相关关系(r=0.520，r=0.669)。结果表明，在常规康复治疗基础上增加双极经颅直流电刺激可以有效改善缺血性脑卒中患者的脑功能及上肢运动功能。上肢运动功能改善与脑功能恢复趋向正常化相关。
https://orcid.org/0009-0004-4516-2078(侯兵)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 经颅直流电刺激, 脑卒中, 双侧刺激, 康复训练, 上肢运动功能, 脑功能, 脑电活动, 神经康复

Abstract: BACKGROUND: In stroke patients, cerebral neurological deficits can further lead to upper limb motor dysfunction, and the recovery of cerebral and upper limb motor functions plays an important role in improving the ability of daily living. Although studies have investigated the immediate effects of a single transcranial direct current stimulation on the electrical activity of the brain in stroke patients, the therapeutic effects of short-term transcranial direct current stimulation need to be further explored.
OBJECTIVE: To evaluate the effects of transcranial direct current stimulation on upper limb motor function and brain function in stroke patients immediately and after 3 weeks of intervention.
METHODS: A total of 30 patients with hemiplegia after ischemic stroke were recruited and randomly divided into an experimental group (n=15) and a control group (n=15). The experimental group received bipolar transcranial direct current stimulation on the basis of conventional rehabilitation, while the control group received pseudo-transcranial direct current stimulation. Treatments in each group lasted for 3 weeks. The Fugl-Meyer rating scale for the upper limb, the Wolf Motor Function Test and resting-state electroencephalography were performed before the intervention, after the first intervention and after 3 weeks of intervention.
RESULTS AND CONCLUSION: (1) There was no significant change in the control group immediately after intervention compared with before intervention, while the Fugl-Meyer rating scale score in the experimental group increased immediately after intervention (P < 0.05). (2) After 3 weeks of intervention, the Fugl-Meyer rating scale score, Wolf Motor Function Test score and electroencephalography frequency band changes were significantly improved in the two groups, and the improvement effect in the experimental group was more obvious (P < 0.05). (3) Correlation analysis showed that the difference between Fugl-Meyer rating scale and Wolf Motor Function Test scores before and after treatment in the experimental group was negatively correlated with the average brain power of δ (r=-0.716 and r=-0.546, respectively), and positively correlated with the average brain power of α (r=0.520 and r=0.669, respectively). To conclude, the addition of bipolar transcranial direct current stimulation to conventional rehabilitation treatment could effectively improve the brain function and upper limb motor function of patients with ischemic stroke. Improvement in upper limb motor function is associated with a tendency toward normalization of brain function recovery.

Key words: transcranial direct current stimulation, stroke, bilateral stimulation, rehabilitation training, upper limb motor function, brain function, brain electrical activity, neurorehabilitation

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