中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (29): 7555-7564.doi: 10.12307/2026.332

• 肌肉肌腱韧带组织构建 tissue construction of the muscle, tendon and ligament • 上一篇    下一篇

磁场线粒体调控技术联合低负荷血流限制对下肢肌群力量的影响

李文昊1，杨  玺1，杜欣冉1，白  石2，3，厉中山1，4   

  1. 1东北大学体育部，辽宁省沈阳市   110819；2沈阳工业大学信息科学与工程学院，辽宁省沈阳市   111003；3辽宁省磁医学检测与治疗专业技术创新中心，辽宁省沈阳市   110034；4福建师范大学体育科学学院，福建省福州市   350117
  • 收稿日期:2025-04-09 修回日期:2025-07-29 出版日期:2026-10-18 发布日期:2026-03-03
  • 通讯作者: 厉中山，长聘副教授，硕士研究生导师，沈阳市领军人才，东北大学体育部，辽宁省沈阳市 110819；福建师范大学体育科学学院，福建省福州市 350117
  • 作者简介:李文昊，男，2003年生，主要从事运动人体科学、磁生物学以及运动促进人体健康研究。
  • 基金资助:
    辽宁省科技计划联合计划(技术攻关计划项目)(2024JH2/102600124)，项目负责人：厉中山；辽宁省国际合作项目(2023JH2/10700004)，项目负责人：白石；国家自然科学基金项目(62471320)，项目负责人：白石；兴辽人才计划项目(XLYC2203046)，项目负责人：白石

Effect of magnetic field mitochondrial regulation technology combined with low-load blood flow restriction on the strength of lower limb muscle groups

Li Wenhao1, Yang Xi1, Du Xinran1, Bai Shi2, 3, Li Zhongshan1, 4   

  1. 1Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; 2College of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China; 3Liaoning Provincial Innovation Center for Magnetic Medicine Detection and Treatment, Shenyang 110034, Liaoning Province, China; 4College of Sports Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China
  • Received:2025-04-09 Revised:2025-07-29 Online:2026-10-18 Published:2026-03-03
  • Contact: Li Zhongshan, Associate professor, Master’s supervisor, Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; College of Sports Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China
  • About author:Li Wenhao, Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China
  • Supported by:
    Liaoning Provincial Science and Technology Program Joint Program (Technology Tackling Program Project), No. 2024JH2/102600124 (to LZS); Liaoning Provincial International Cooperation Project, No. 2023JH2/10700004 (to BS); National Natural Science Foundation of China, No. 62471320 (to BS); Xingliao Talent Program Project, No. XLYC2203046 (to BS)

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摘要：



文题释义：
血流限制训练：通过在运动过程中对肢体近端施加适度压力，限制部分静脉血液回流而不完全阻断动脉血流，为外周肢体的肌肉创造出缺血缺氧的环境。大量研究证实，低负荷抗阻训练与血流限制技术相结合能够达到高强度抗阻训练的效果。
磁场线粒体调控技术：通过特定磁刺激参数激活经典瞬时受体电位通道1，进而触发钙-线粒体轴级联反应，该生理过程通过上调过氧化物酶体增殖物激活受体γ共激活因子1α的转录活性，显著增强线粒体生物发生与肌生成能力。低频脉冲磁场诱导的钙离子内流可特异性激活钙调神经磷酸酶-T细胞活化核因子信号通路，触发骨骼肌适应性重塑的关键分子开关，成功模拟了运动训练诱导的代谢适应特征，可对骨骼肌功能与结构产生一系列生理支持与适应变化。

背景：磁场线粒体调控技术在骨骼肌功能提升方面的作用已得到证实，低负荷血流限制训练通过代谢应激机制可有效诱导肌肉力量的适应性增长，目前两项技术成为骨骼肌功能提升与治疗应用与研究的热点。然而，两项技术对肌肉力量提升效果的差异以及联合应用是否会产生增效效应尚不清楚。
目的：观察低频脉冲磁刺激(1.5 mT，3 300 Hz)与低负荷血流限制训练对肌肉力量提升效果的差异与联合干预对下肢肌群力量的影响。
方法：招募普通健康受试者56名，随机分为磁刺激组(高负荷负重半蹲训练+磁刺激)、血流限制组(低负荷血流限制负重半蹲训练)、联合组(低负荷血流限制负重半蹲训练+磁刺激)以及对照组(高负荷负重半蹲训练)，试验时长共计4周，训练为每周3次，每48 h进行一次低频脉冲磁刺激(1.5 mT，3 300 Hz)，试验结束后观察不同组别受试者下肢干预肌群最大力量、爆发力、力量耐力相关指标的变化。
结果与结论：50名受试者完成试验进入结果分析。①经过4周的干预，磁刺激组、血流限制组和联合组受试者的下肢最大力量、爆发力以及力量耐力指标均显著增长。②最大力量增长方面，血流限制效果优于磁场调控线粒体技术，低负荷血流限制还可对远端肌群力量产生增强效果，而磁场线粒体调控技术优势在于无疲劳累积的情况下提升最大力量。③爆发力增长方面，两技术提升效果一致，磁刺激对单关节发力的爆发力促进方面更具优势，而低负荷血流限制训练对多关节协同发力的爆发力提高更具优势。④力量耐力增长方面，磁刺激技术因具备线粒体功能调控作用可有效对肌肉抗疲劳能力产生更好的提升效果。结果提示：磁刺激与低负荷血流限制联合应用可对下肢最大力量、爆发力、力量耐力产生增效效应，该技术方案可为无法进行高强度抗阻训练的术后康复及运动损伤患者提供一种新型、高效的下肢肌群力量辅助增效的训练方案。
https://orcid.org/0000-0002-9010-609X (厉中山)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 下肢肌力, 血流限制训练, 低频脉冲磁刺激, 线粒体, TRPC 1

Abstract: BACKGROUND: The magnetic field mitochondrial regulation technology has been proven to enhance skeletal muscle function. Low-load blood flow restriction training can effectively induce adaptive growth of muscle strength through metabolic emergency mechanisms. Currently, both technologies have become hotspots in the application and research of skeletal muscle function improvement and treatment. However, the differences in their effects on muscle strength enhancement and whether their combined application can produce a synergistic effect remain unclear. 
OBJECTIVE: To observe the differences in the effects of low-frequency pulsed magnetic stimulation (1.5 mT, 3 300 Hz) and low-load blood flow restriction training on muscle strength enhancement and the impact of their combined intervention on lower limb muscle strength. 
METHODS: Fifty-six healthy subjects were recruited and randomly divided into the magnetic stimulation group (high-load half squat training), the blood flow restriction group (low-load blood flow restriction+half squat training), the combined group (magnetic stimulation and low-load blood flow restriction+half squat training), and the control group (high-load half squat training). The intervention lasted for 4 weeks, with subjects in each intervention group receiving low-frequency pulsed magnetic stimulation (1.5 mT, 3 300 Hz) every 48 hours, three times a week. After the intervention, changes in the maximum strength, explosive power, and strength endurance of the lower limb muscles in each group were observed. 
RESULTS AND CONCLUSION: Fifty subjects were included in the result analysis after completing the trial. (1) After 4 weeks of intervention, all three intervention groups showed significant increases in the maximum strength, explosive power, and strength endurance of the lower limb muscles. (2) In terms of maximum strength growth, the blood flow restriction group had a better effect than the magnetic field mitochondrial regulation technology. Low-load blood flow restriction also enhanced the strength of distal muscle groups, while the magnetic field mitochondrial regulation technology had the advantage of increasing maximum strength without fatigue accumulation. (3) In terms of explosive power growth, both technologies had similar effects, but magnetic stimulation was more effective in promoting explosive power in single-joint movements, while low-load blood flow restriction training was more effective in improving explosive power in multi-joint coordinated movements. (4) In terms of strength endurance growth, magnetic stimulation technology, due to its regulation of mitochondrial function, was more effective in enhancing the anti-fatigue ability of muscles. To conclude, the combined application of magnetic stimulation and low-load blood flow restriction can produce a synergistic effect on the maximum strength, explosive power, and strength endurance of the lower limbs. This technology protocol can provide a new and efficient training method for enhancing lower limb muscle strength for patients who cannot perform high-intensity resistance training, such as those in postoperative rehabilitation or with sports injuries. 


Key words: lower limb muscle strength, blood flow restriction training, low-frequency pulsed magnetic stimulation, mitochondria, TRPC 1

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