中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (19): 5066-5071.doi: 10.12307/2026.115

• 干细胞循证医学 evidence-based medicine of stem cells • 上一篇    下一篇

人脐血间充质干细胞对膝骨关节病患者疼痛和功能影响的Meta分析

刘彦哲1，刘  华1，杨土保2，3，刘育鹏1   

  1. 1中南大学湘雅医院骨科，湖南省长沙市   410008；2中南大学湘雅公共卫生学院流行病学与卫生统计学系，湖南省长沙市   410013；3临床流行病学湖南省重点实验室，湖南省长沙市   410013
  • 收稿日期:2025-04-03 接受日期:2025-06-24 出版日期:2026-07-08 发布日期:2026-02-24
  • 通讯作者: 刘育鹏，博士，副教授，中南大学湘雅医院骨科，湖南省长沙市 410008
  • 作者简介:刘彦哲，男，1997年生，湖南省长沙市人，汉族，硕士，助教，主要从事骨关节退行性疾病的危险因素及发病机制研究。
  • 基金资助:
    湖南省自然科学基金面上项目(2021JJ31085)，项目负责人：刘育鹏；教育部产学合作协同育人项目2023年批次(230824582607228)，项目负责人：刘彦哲

Effects of human umbilical cord blood mesenchymal stem cells on pain and function in patients with knee osteoarthritis: a meta-analysis

Liu Yanzhe1, Liu Hua1, Yang Tubao2, 3, Liu Yupeng1   

  1. 1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China; 2Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha 410013, Hunan Province, China; 3Key Laboratory of Clinical Epidemiology of Hunan Province, Changsha 410013, Hunan Province, China
  • Received:2025-04-03 Accepted:2025-06-24 Online:2026-07-08 Published:2026-02-24
  • Contact: Liu Yupeng, MD, Associate professor, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
  • About author:Liu Yanzhe, MS, Teaching assistant, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
  • Supported by:
    Hunan Natural Science Foundation (General Project), No. 2021JJ31085 (to LYP); Ministry of Education Industry-University Cooperation Collaborative Education Project (2023 Batch), No. 230824582607228 (to LYZ)

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摘要：

文题释义：

人脐血间充质干细胞：是从新生儿脐血中提取的一种多能干细胞，具有自我更新和多向分化潜能。人脐血间充质干细胞治疗膝骨关节病的作用机制包括促进软骨修复、抑制炎症反应和调节免疫微环境。
膝骨关节病：是一种以关节软骨退行性变和继发性骨质增生为特征的慢性关节疾病。该病症主要表现为关节疼痛、肿胀、活动受限，严重时可导致关节畸形和功能障碍。

摘要
目的：采用Meta分析人脐血间充质干细胞对膝骨关节病患者疼痛和功能的影响。
方法：以“人脐血，间充质干细胞，膝骨关节病”为中文检索词，以“human cord blood，mesenchymal stem cell，MSC，knee osteoarthritis，knee joint disease，knee joint disorders，knee OA”为英文检索词，检索中国知网、万方、维普、PubMed、Elsevier、Web of Science数据库，检索时限从各数据库建库至2024-06-13。纳入文献质量评价使用Corchrane偏倚风险评估工具和ROBINS-I工具，Meta分析选择Revman软件，对于连续性变量计算均数差，对于二分类变量计算相对危险度，另计算95%置信区间。
结果：纳入随机对照试验3篇，病例-对照研究3篇，合计248例研究对象，文献质量评价中等。Meta分析结果显示：①试验组患者目测类比评分低于对照组，差异有显著性意义(χ2=44.98，P < 0.001，I2=91%)；②试验组患者西安大略和麦克马斯特大学膝骨关节病指数低于对照组，差异有显著性意义(χ2=16.84，P < 0.001，I2=88%)；③试验组患者Lysholm膝关节功能评分高于对照组，差异有显著性意义(χ2=0.12，P=0.73，I2=0%)；④试验组患者不良反应发生率高于对照组，差异有显著性意义(χ2=4.99，P < 0.001，I2=20%)，合并风险差为0.21，折算成所需治疗人数为5。

结论：人脐血间充质干细胞可以减轻膝骨关节病患者的疼痛，改善膝关节功能，并在安全性与有效性之间实现了良好的平衡。

https://orcid.org/0000-0001-6252-1491 (刘育鹏) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 人脐血间充质干细胞, 膝骨关节病, 软骨损伤, Meta分析, 目测类比评分, 西安大略和麦克马斯特大学膝骨关节病指数, 膝关节功能评分, 不良反应

Abstract: OBJECTIVE: To conduct a meta-analysis concerning the effects of human umbilical cord blood mesenchymal stem cells on pain and function in patients with knee osteoarthritis.
METHODS: Using the Chinese search terms “human umbilical cord blood, mesenchymal stem cells, knee joint-related diseases” and the English search terms “human cord blood, mesenchymal stem cell, MSC, knee osteoarthritis, knee joint disease, knee joint disorders, knee OA,” we conducted searches in the CNKI, WanFang, VIP, PubMed, Elsevier, and Web of Science databases. The search timeframe spanned from the establishment of each database until June 13, 2024. The quality of the included literature was assessed using the Cochrane Risk of Bias tool and the ROBINS-I tool. For meta-analysis, the Revman software was utilized, calculating mean differences for continuous variables and relative risks for dichotomous variables, along with 95% confidence intervals. 
RESULTS: Three randomized controlled trials and three case-control studies involving a total of 248 subjects were included, with the quality of the literature evaluated as moderate. The results of the meta-analysis showed that (1) visual analog scale score was significantly lower in the trial group than in the control group, with significant differences (χ2=44.98, P < 0.001, I²=91%). (2) The Western Ontario and McMaster Universities Osteoarthritis Index score was significantly lower in the trial group than in the control group, with significant differences (χ2=16.84, P < 0.001, I²=88%). (3) The Lysholm scoring system score was significantly higher in the trial group than in the control group, with significant differences (χ2=0.12, P=0.73, I²=0%). (4) The incidence of adverse reactions was significantly higher in the trial group than in the control group, with significant differences (χ2=4.99, P < 0.001, I²=20%), with a pooled risk difference of 0.21, corresponding to a number needed to treat of 5. 
CONCLUSION: Human umbilical cord blood mesenchymal stem cells can relieve pain in patients with knee osteoarthritis, improve knee function, and achieve a good balance between safety and effectiveness. 


Key words: human umbilical cord blood mesenchymal stem cell, osteoarthritis, cartilage injury, meta-analysis, visual analog scale score, Western Ontario and McMaster Universities Osteoarthritis Index, knee function score, adverse reactions

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