中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (22): 4795-4803.doi: 10.12307/2025.466

• 生物材料综述 biomaterial review • 上一篇    下一篇

自组装短肽水凝胶治疗肿瘤的作用

贺欢欢1，2，田诗佳1，2，陈罗英1，2，刘燕飞1，2   

  1. 1遵义医科大学附属医院细胞工程重点实验室，贵州省遵义市   563000；2遵义医科大学组织损伤修复与再生医学省部共建协同创新中心，贵州省遵义市   563000
  • 收稿日期:2024-06-22 接受日期:2024-07-27 出版日期:2025-08-08 发布日期:2024-12-06
  • 通讯作者: 刘燕飞，副教授，遵义医科大学附属医院细胞工程重点实验室，贵州省遵义市 563000；遵义医科大学组织损伤修复与再生医学省部共建协同创新中心，贵州省遵义市 563000
  • 作者简介:贺欢欢，女，2001年生，湖北省黄冈市人，汉族，在读硕士，主要从事自组装短肽相关设计和研究。
  • 基金资助:
    贵州省科技厅基础研究项目(黔科合基础-ZK[2024]316)，项目负责人：刘燕飞

Effects of self-assembling peptide hydrogels on tumor treatment

He Huanhuan1, 2, Tian Shijia1, 2, Chen Luoying1, 2, Liu Yanfei1, 2   

  1. 1Key Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China; 2Organizational Injury Repair and Regenerative Medicine Provincial and Departmental Collaborative Innovation Center, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Received:2024-06-22 Accepted:2024-07-27 Online:2025-08-08 Published:2024-12-06
  • Contact: Liu Yanfei, Associate professor, Key Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China; Organizational Injury Repair and Regenerative Medicine Provincial and Departmental Collaborative Innovation Center, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • About author:He Huanhuan, Master candidate, Key Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China; Organizational Injury Repair and Regenerative Medicine Provincial and Departmental Collaborative Innovation Center, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Supported by:
    Basic Research Project of Guizhou Provincial Department of Science and Technology, No. ZK[2024]316 (to LYF)

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摘要：


文题释义：

自组装短肽水凝胶：短肽是由氨基酸组成的小分子肽链。当短肽溶液浓度高于临界聚集浓度时，能够通过静电作用、氢键、疏水作用等微作用力，自组装成为纳米纤维结构，形成高含水量的三维凝胶。
缓释载体：以可控的速率释放药物成分，用于延长药物的作用时间、减少用药频率、提高疗效及靶向性。一种或多种药物可以通过不同的技术手段包裹在水凝胶内，从而达到缓释的效果，使药物能够在治疗部位长时间维持在有效浓度范围内，持续发挥治疗作用。


背景：自组装短肽水凝胶具有良好的生物相容性、可控的物理化学性质和释放性能，在组织工程、药物输送和生物传感等领域具有广泛的应用潜力。

目的：总结近年来自组装短肽水凝胶在肿瘤治疗中的研究进展。
方法：以“自组装短肽，水凝胶，缓释载体，抗肿瘤，肿瘤治疗；Self-assembling peptide，hydrogel，sustained release，antitumor，tumor therapy”为检索词，检索中国知网、PubMed、Elsevier ScienceDirect数据库2000-2024年发表的相关文献，最终纳入81篇文献进行综述。

结果与结论：自组装短肽水凝胶作为一种新型的生物活性材料，可以作为缓释药物载体负载多种抗肿瘤药物、免疫抑制剂等，靶向肿瘤部位、诱导肿瘤细胞死亡、降低药物使用剂量、提高肿瘤部位药物蓄积量，从而降低毒副作用和多药耐药性的产生概率。此外，具有天然活性的抗肿瘤水凝胶能够不依赖于药物直接杀伤肿瘤细胞，单独使用能够最大限度避免抗肿瘤药物的毒副作用。

https://orcid.org/0009-0003-5676-8262 (贺欢欢) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 自组装短肽, 水凝胶, 药物缓释, 抗肿瘤, 组织工程

Abstract: BACKGROUND: Self-assembling peptide hydrogels exhibit excellent biocompatibility, controllable physicochemical properties, and release capabilities, offering extensive application potential in tissue engineering, drug delivery, and biosensing fields.
OBJECTIVE: To summarize the research progress of self-assembling peptide hydrogel in cancer therapy in recent years.
METHODS: Using the search terms “self-assembling peptides, hydrogel, sustained release, antitumor, tumor therapy” in Chinese and English, CNKI, PubMed, and Elsevier ScienceDirect databases were searched for relevant literature published from 2000 to 2024. Finally, 81 articles were included in the review. 
RESULTS AND CONCLUSION: Self-assembling peptide hydrogels, as a novel biomaterial, can be used as a sustained-release drug carrier to load a variety of anti-tumor drugs, and immunosuppressants, targeting tumor sites, inducing tumor cell death, reducing drug dosage, and increasing drug accumulation in tumor sites, thereby reducing the probability of toxic side effects and multidrug resistance. Moreover, anti-tumor hydrogels with natural activity can directly kill tumor cells without relying on drugs, and can minimize the toxic side effects of anti-tumor drugs when used alone.

Key words: self-assembling peptide, hydrogel, sustained release, anti-tumor, tissue engineering

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