中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4829-4832.doi: 10.3969/j.issn.1673-8225.2011.26.020

• 骨与关节生物力学 bone and joint biomechanics • 上一篇    下一篇

去卵巢骨质疏松模型大鼠L4脊椎骨的应力松弛与蠕变

张  翘1，张忠君2，李新颖1   

  1. 1吉林大学中日联谊医院，吉林省长春市  130031
    2解放军空军航空大学基础部，吉林省长春市130022
  • 收稿日期:2011-04-08 修回日期:2011-05-30 出版日期:2011-06-25 发布日期:2011-06-25
  • 作者简介:张翘☆，男，1977年生，吉林省长春市人，汉族，2004年吉林大学中日联谊医院毕业，博士，主治医师，主要从事骨科临床与生物力学研究。 mahs@jlu.edu.cn

L4 vertebra stress relaxation and creep properties in ovariectomized rats with osteoporosis 

Zhang Qiao1, Zhang Zhong-jun2, Li Xin-ying1   

  1. 1China-Japan Union Hospital of Jilin University, Changchun  130031, Jilin Province, China
    2Department of Basic, Air Force Aviation University of Chinese PLA, Changchun  130022, Jilin Province, China
  • Received:2011-04-08 Revised:2011-05-30 Online:2011-06-25 Published:2011-06-25
  • About author:Zhang Qiao☆, Doctor, Attending physician, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn

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887

被引次数

8

摘要：

背景：去卵巢大鼠脊椎骨会发生哪些应力松弛与蠕变及时间的变化规律？
目的：观察去卵巢骨质疏松对雌性大鼠承重骨黏弹性特性的影响。
方法：Wistar雌性大鼠44只随机等分为对去卵巢骨质疏松动物模型组和对照组。模型组大鼠于0周摘除卵巢，14周后对大鼠L4椎骨进行应变增加速度为1%/s的应力松弛实验和应力增加速度为0.01 MPa/s的蠕变实验，在7 200 s采集100个数据。
结果与结论：大鼠L4椎骨对照组7 200 s应力松弛量和蠕变量大于模型组(P < 0.05)；同时大鼠L4椎骨应力松弛曲线是以对数关系变化的，蠕变曲线是以指数关系变化的。提示去卵巢骨质疏松大鼠椎骨黏弹性力学特性发生了改变。

关键词: 去卵巢, 骨质疏松, L4椎骨, 流变特性, 大鼠

Abstract:

BACKGROUND: For the prevention and treatment of osteoporosis, it is necessary to understand the relationships of the creep and stress relaxation of the spine with time in ovariectomized rats.
OBJECTIVE: To observe the osteoporosis effects on the viscoelastic properties of load-bearing bone of ovariectomized female rats.
METHODS: Forty-four Wistar female rats were divided into control and osteoporosis model groups. Rats in the model group were ovariectomized at 0 week. Stress relaxation trial with 1%/s strain rate and creep experiment with 0.01 MPa/s stress increasing rate. 100 data were collected within 7 200 seconds.
RESULTS AND CONCLUSION: The amount of stress relaxation and creep on L4 segment within 7 200 seconds was higher in the control group than the model group (P < 0.05). The stress relaxation curve changed in logarithmic manner, and the creep curve changed in exponential manner. The viscoelastic properties of ovariectomized rats with osteoporosis have changes.

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