Interferon-gamma and interleukin-10 levels in serum and saliva are related to different types of oral lichen planus

Abstract

Abstract:

BACKGROUND: Many cytokines can be detected in saliva and serum, and have more clinical significance in the diagnosis, prognosis and treatment of oral mucosa disease.
OBJECTIVE: To compare the interferon-γ and interleukin-10 levels in serum and saliva of patients with different types of oral lichen planus and to explore the feasibility of saliva samples as a substitute of blood samples to study the interferon-γ and interleukin-10 levels in serum and saliva.
METHODS: Totally 45 patients with oral lichen planus admitted at the Department of Periodontology, the Stomatological Hospital of Jiamusi University from January to July 2014 were enrolled, including 15 cases of erosion type (erosion group), 15 cases of congestive erythema (congestive erythema group) and 15 cases of reticulate type (reticulate group). Another 15 healthy controls admitted for physical examination at the Department of Physical Examination, the Stomatological Hospital of Jiamusi University were enrolled as controls. ELISA method was used to detect the interferon-γ and interleukin-10 levels in serum and saliva in the four groups.
RESULTS AND CONCLUSION: Compared with the control group, the interferon-γ levels in serum and saliva were lower in the other three groups (P < 0.01), while there were significant differences in the interferon-γ level among the patients with different types of oral lichen planus (P < 0.01). The interleukin-10 levels in serum and saliva were significantly higher in the erosion group and congestive erythema group than those in the control group (P < 0.01 or P < 0.05) and reticulate group P < 0.01 or P < 0.05). Experimental findings suggest that the levels of interferon-γ and interleukin-10 in serum and saliva are highly correlated in patients with different types of oral lichen planus, and saliva samples can be instead of blood samples to detect the levels of interferon-γ and interleukin-10 in patients with oral lichen planus.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Interferon-gamma, Interleukin-10, Serum, Saliva

CLC Number:

R318

Zhu Jian-hua, Liu Na, Zhao Chang-rong, Liu Ji-guang. Interferon-gamma and interleukin-10 levels in serum and saliva are related to different types of oral lichen planus[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(2): 236-240.

Figures/Tables 1

References

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