Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (19): 3102-3108.doi: 10.3969/j.issn.2095-4344.1258

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Biomarkers of rheumatoid arthritis: performance analysis of antibodies from serum and synovial fluid

Wang Zhi1, Lin Yipeng2, Li Qi3   

  1.  (1Department of Joint, the First Orthopedic Hospital of Chengdu, Chengdu 610041, Sichuan Province, China; 2Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; 3Department of Sports Medicine, Wenjiang Branch of West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China)
  • Received:2018-12-27
  • Contact: Li Qi, Associate chief physician, Department of Sports Medicine, Wenjiang Branch of West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Wang Zhi, Attending physician, Department of Joint, the First Orthopedic Hospital of Chengdu, Chengdu 610041, Sichuan Province, China

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Abstract:

BACKGROUND: The sensitivity and specificity of common rheumatoid factor are not high in the diagnosis of rheumatoid arthritis. Anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody are gradually used, but their serum contents associated with synovial fluid concentration remain unclear.
OBJECTIVE: To evaluate the application value of anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody in the early diagnosis of rheumatoid arthritis.
METHODS: Anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody levels in serum and synovial fluid in 16 patients with early rheumatoid arthritis and 6 cases of other diseases (excluding rheumatoid arthritis) were detected by ELISA, and other clinical data were collected. The sensitivity and specificity of serum anti-cyclic citrullinated peptide antibody in serum and synovial fluid were calculated, respectively to explore its correlation.
RESULTS AND CONCLUSION: (1) The sensitivity and specificity of serum anti-cyclic citrullinated peptide antibody were good in the diagnosis of early rheumatoid arthritis, which could be used as a serum indicator. The sensitivity and specificity of synovial fluid anti-cyclic citrullinated peptide antibody was the same with the serum anti-cyclic citrullinated peptide antibody. (2) The sensitivity and specificity of serum anti-modified citrullinated vimentin antibody were good in the diagnosis of early rheumatoid arthritis, which had the similar value with anti-cyclic citrullinated peptide antibody. (3) The sensitivity and specificity of serum rheumatoid factor in diagnosis of early rheumatoid arthritis were lower than those of anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody. (4) In summary, the combined detection of anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody can improve the diagnosis results. There is positive correlation between anti-cyclic citrullinated peptide antibody and anti-modified citrullinated vimentin antibody. 

Key words: rheumatoid arthritis, anti-cyclic citrullinated peptide antibody, anti-modified citrullinated vimentin antibody, rheumatoid factors, synovial fluid anti-cyclic citrullinated peptide antibody, serum anti-cyclic citrullinated peptide antibody, cryoglobulinemia

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