Assessment of seven joint ultrasound score for early rheumatoid arthritis

doi:10.3969/j.issn.2095-4344.1209

Abstract

Abstract:

BACKGROUND: Early discovery, diagnosis and treatment are critical for the prevention and treatment of early rheumatoid arthritis. Ultrasound scoring system can provide quantified data for the disease diagnosis and treatment.

OBJECTIVE: To study the application value of seven joint ultrasound score in the diagnosis and treatment of early rheumatoid arthritis.

METHODS: Fifty patients with early rheumatoid arthritis were as observation group, and 70 healthy subjects were as control group. All subjects were examined by high-frequency ultrasound. The joints included wrist joints, proximal interphalangeal joint of the second finger, proximal interphalangeal joint of the third finger, metacarpophalangeal joint of the second finger, metacarpophalangeal joint of the third finger, second metatarsophalangeal joint and fifth metatarsophalangeal joint. The seven joint ultrasound scores were compared between two groups. According to the clinical data, the seven joint ultrasound scores of patients with early rheumatoid arthritis at different stages of disease activity, function classification and grading signs were compared. The serum levels of high-sensitivity C-reactive protein and interleukin-6 were detected in the observation group. The seven joint ultrasound scores were compared between high-sensitivity C-reactive protein and interleukin-6 positive and negative groups.

RESULTS AND CONCLUSION: (1) The average score of seven joints in the observation group was higher than that in the control group (P < 0.05), and the average seven joint ultrasound score was higher than that in the control group (P < 0.05). (2) For the average seven joint ultrasound score, staging of disease activity in moderate severe group > stable and mild activity group (P < 0.05), grade III-IV group > grade I-II group (P < 0.05), sign grade II-III group > sign grade 0-I group (P < 0.05), and high-sensitivity C-reactive protein and interleukin-6 positive group > negative group (P < 0.05). (3) To conclude, the seven joint ultrasound score can fully describe the basic clinical characteristics of early rheumatoid arthritis, and can evaluate the disease activity, functional activity, the inflammatory degree and the degree of joint injury, so as to provide a reference for the diagnosis and treatment of early rheumatoid arthritis.

Key words: rheumatoid arthritis, seven joint ultrasound score, early diagnosis, pathological features, inflammatory, high-sensitivity C-reactive protein, interleukin-6

CLC Number:

R445.1

Hu Xiaoli, Gu Ying, Cai Yan, Xie Jin, Liu Chan. Assessment of seven joint ultrasound score for early rheumatoid arthritis[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(16): 2523-2528.

Figures/Tables 5

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