Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (26): 4173-4179.doi: 10.12307/2022.820
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Liu Ya1, 2, Liu Xia1, Deng Penghui1, Ji Wei1, Li Jianping1
Received:
2021-06-29
Accepted:
2021-09-18
Online:
2022-09-18
Published:
2022-03-08
Contact:
Liu Xia, Professor, Master’s supervisor, Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, School of Physical Education of Hunan Normal University, Changsha 410012, Hunan Province, China
About author:
Liu Ya, Master, Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, School of Physical Education of Hunan Normal University, Changsha 410012, Hunan Province, China; Hunan International Economics University, Changsha 410205, Hunan Province, China
Supported by:
CLC Number:
Liu Ya, Liu Xia, Deng Penghui, Ji Wei, Li Jianping. Exercise effects on myocardial type I, III collagen and angiotensin II/transforming growth factor beta1/Smad2 pathway in diabetic myocardial fibrosis rats[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(26): 4173-4179.
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苏木精-伊红染色:空白对照组大鼠心肌细胞排列整齐,细胞形态、大小、间隙正常,细胞核均匀分布;糖尿病模型组大鼠心肌细胞排列较紊乱,细胞形态、大小异常,细胞间隙增宽,有炎性细胞浸润;糖尿病运动组大鼠心肌细胞排列尚整齐,细胞形态、大小异常,细胞间隙基本正常。 Masson染色:空白对照组间质蓝染面积小,纤维化不明显;糖尿病模型组间质蓝染面积明显增加,有明显的纤维化;糖尿病运动组间质蓝染面积减少,有少许纤维化改变。Masson染色半定量结果显示,与空白对照组相比,糖尿病模型组大鼠心肌纤维胶原容积分数增加(P < 0.01);与糖尿病模型组相比,糖尿病运动组大鼠心肌纤维胶原容积分数减少(P < 0.01)。 2.4 各组大鼠心肌组织Ⅰ、Ⅲ型胶原纤维免疫组织化染色结果 见图2。"
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