Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (8): 1305-1312.doi: 10.3969/j.issn.2095-4344.3047

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Effect of acute high-intensity exercise on appetite hormones in adults: a meta-analysis

Wang Yongsheng1, Wu Yang2, Li Yanchun2   

  1. 1China Agricultural University, Beijing 100193, China; 2Beijing Sport University, Beijing 100084, China
  • Received:2020-05-11 Revised:2020-05-16 Accepted:2020-07-03 Online:2021-03-18 Published:2020-12-14
  • Contact: Li Yanchun, PhD, Associate researcher, Beijing Sport University, Beijing 100084, China
  • About author:Wang Yongsheng, Master, Lecturer, China Agricultural University, Beijing 100193, China
  • Supported by:
    the National Key Research & Development Program of China, No. 2018YFC2000600

Abstract: OBJECTIVE: Acute high-intensity exercise can temporarily suppress appetite, but the effect of appetite hormones in this process is inconclusive. Meta-analysis is used to explore the effects of acute high-intensity exercise on adult appetite hormones, and provide theoretical basis for the follow-up research on the effects of exercise on appetite hormones.
METHODS: Chinese and International databases such as CNKI, WanFang, Web of Science, PubMed and other databases were searched for articles regarding the effects of acute high-intensity exercise on appetite hormones. The literature search time span was from inception to August 17, 2019. The subjects included in the article were all adults. The intervention measure was a single high-intensity exercise. The outcome indicators were one or combination of acylated ghrelin, peptide YY, peptide YY 3-36, pancreatic polypeptide, and pancreatic height, and glucagon-like peptide-1 expressed by area under curves. In this meta-analysis, an improved version of Cochrane risk bias tool was used to evaluate methodological quality, and Revman 5.3 and STATA15.0 software were used for the meta-analysis of the outcome indicators of the included literature.
RESULTS: A total of 18 research literatures were included, with a total of 212 subjects, including 179 males and 33 females. The literature quality evaluation results showed that the overall literature quality was high. Meta-analysis results showed that acute high-intensity exercise could significantly inhibit acylated ghrelin level (standardized mean difference (SMD)=-0.27, 95% confidence interval (CI):-0.45 to -0.08, P < 0.05), and significantly increase peptide YY (SMD=-0.31, 95%CI: 0.07-0.54, P < 0.05). Although there was an increase in the levels of peptide YY 3-36 (SMD=0.29, 95%CI: -0.19 to 0.77, P ﹥ 0.05), pancreatic polypeptide (SMD=0.37, 95%CI: -0.07 to 0.81, P ﹥ 0.05), and glucagon-like peptide-1 (SMD=0.29, 95%CI: -0.17 to 0.75, P ﹥ 0.05) after acute high-intensity exercise, it had no significant significance. 
CONCLUSION: Overall, acute high-intensity exercise has a certain effect on the level of appetite hormones, which can significantly inhibit orexigenic hormones and increase anorexigenic gastrointestinal hormones. The results suggest that acute high-intensity exercise can effectively regulate the secretion of appetite hormones, thereby controlling appetite and food intake, and can play a positive role in weight management. But future large-sample trials are needed.

Key words: exercise, hormone, appetite, peptide, exercise intensity, body mass, adult, meta-analysis

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