Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (18): 2833-2841.doi: 10.3969/j.issn.2095-4344.1671
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Received:
2019-01-14
Online:
2019-06-28
Published:
2019-06-28
Contact:
Wang Liming, Associate chief physician, Department of Orthopedics, Zhangjiagang First People’s Hospital, Suzhou 215000, Jiangsu Province, China
About author:
Zhao Kangquan, Master, Physician, Department of Orthopedics, Zhangjiagang First People’s Hospital, Suzhou 215000, Jiangsu Province, China
Supported by:
the Science and Education Youth Science Foundation of Suzhou, No. KJXW2017059 (to ZKQ)
CLC Number:
Zhao Kangquan, Pi Bin, Sha Weiping, Ge Jianfei, Yang Huilin, Wang Liming. Preparation and properties of degradable polymethyl methacrylate bone cement incorporated with N-acetyl cysteine[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(18): 2833-2841.
图2可见,随着加入2-亚甲基-1,3-二氧杂环庚烷含量的增加,骨水泥的抗压强度出现了下降趋势,统计学结果提示各组间的抗压强度比较差异有显著性意义(P < 0.05),两两比较后发现,传统骨水泥与NAC/10%MDO骨水泥的抗压强度差异有显著性意义(P < 0.05),而与其他组的比较差异均无显著性意义(P > 0.05)。所以选择第4组NAC/5%MDO骨水泥,即不明显降低抗压强度时含最高2-亚甲基-1,3-二氧杂环庚烷比例的骨水泥,用于后续实验。 2.2 骨水泥凝固时间 骨水泥凝固时间,见表3,两组骨水泥的拉丝期及面团期比较差异均无显著性意义(P > 0.05),提示在骨水泥液体组分中加入25 mmol/L N-乙酰半胱氨酸及体积分数5%2-亚甲基-1,3-二氧杂环庚烷时,不明显影响骨水泥的操作性能。"
2.5 骨水泥的降解性能 图5显示骨水泥在冰醋酸中浸泡1 d时的外观表现,可见2组骨水泥均发生明显的溶胀坍塌,但C-PMMA骨水泥聚合长链未发生降解,粉体组分仍包埋于聚合体中,液体澄清;NAC/5%MDO骨水泥的聚合长链发生降解断裂,粉体组分无法继续被包埋于聚合体中而扬至周围液体中,使液体明显浑浊。数均分子质量结果证实了这一点,C-PMMA骨水泥浸泡于冰醋酸1,5 d后的数均分子质量较浸泡前未发生统计学意义上的变化(P > 0.05);NAC/5%MDO骨水泥在醋酸中浸泡1 d后的数均分子质量下降50.4%,浸泡1,5 d后的数均分子质量与浸泡前比较差异均有显著性意义(P < 0.05),浸泡1,5 d的数均分子质量比较差异无显著性意义(P > 0.05),见图6。"
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