BACKGROUND: Silver dressings have good anti-infective effect, but there is still a lack of evidence from randomized controlled studies on the efficacy of silver dressings in the treatment of chronic infected wounds.
OBJECTIVE: To systematically evaluate the efficacy of silver dressings in the treatment of chronic infected wounds.
METHODS: Databases of PubMed, Cochrane Library, EMbase, Web of science, CNKI, CBM, WanFang and Baidu Scholar were searched for the randomized controlled trials reporting the efficacy of silver dressings on chronic infected wounds published before August 2018. Literature screening, data extraction and quality assessment were conducted by two researchers, and a meta-analysis was performed on RevMan 5.3 software.
RESULTS AND CONCLUSION: Nine randomized controlled trials including 1 268 patients were enrolled. The trial group was treated with silver dressings, and the control group was treated with dialginate dressings, conventional dressings, foam dressings, general dressings, sterile gauze, vaseline gauze, sterilized gauze or povidone iodine gauze. The meta-analysis results showed that compared with the control group, the wound healing rate in the trial group was increased [OR=4.53, 95%CI (2.87, 7.15), P < 0.000 01], the rate of wound area reduction was increased [MD=8.90, 95%CI (2.05, 15.76), P=0.01], the times of dressing change was decreased [MD=-8.91, 95%CI (-14.33, -3.48), P=0.001], and the debridement time was shortened [MD=-8.92, 95%CI (-10.03, -7.81), P < 0.000 01]. To conclude, silver dressings can promote healing of chronic infected wounds.