Three-dimensional printing orthopedic implants combined with low-intensity whole-body vibration load repairs bone defect and contributes to osseointegration

doi:10.3969/j.issn.2095-4344.1111

Abstract

Abstract:

BACKGROUND: How to improve the integration of titanium alloy implant with bones and repair results is an important issue in the treatment of bone defects.

OBJECTIVE: To study the effects of three-dimensional printed orthopedic implants combined with low-intensity whole-body vibration load on bone defect repair and osseointegration.

METHODS: Twenty-four male New Zealand white rabbits were selected for establishing the model of lateral condyle of femur, and randomly divided into observation and control groups (n=12 per group). The control group was treated with porous titanium alloy implants by three-dimensional printing technique, while the observation group was treated with low-intensity whole-body vibration load on the basis of the control group. The morphological parameters, mineralization, osseointegration, and maximal extraction force of rabbit bone tissue were compared between two groups.

RESULTS AND CONCLUSION: (1) At 6 and 12 weeks of whole-body vibration stimulation, the parameters of bone tissue in the observation group were better than those in the control group. The relative volume of trabecular bone, trabecular thickness and trabecular bone in the observation group were significantly higher than those in the control group. The resolution and relative trabecular bone surface area in the observation group were significantly lower than those in the control group (P < 0.05). (2) After 6 and 12 weeks of whole-body vibration stimulation in the observation group, the mineralization area ratio, mineralization deposition rate, bone formation rate and maximum extraction force were significantly higher than those in the control group, and the maximum extraction force in the two groups was significantly higher at 12 weeks than that at 6 weeks (P < 0.05). (3) These results indicate that three-dimensional printing of orthopedic implants combined with low-intensity whole-body vibration load can effectively promote the growth of bone tissue, accelerate the repair of bone defects, and improve the effect of osseointegration.

Key words: Tissue Engineering, Titanium, Femur

CLC Number:

R459.9|R615

Li Li, Zhao Yiting, He Shikai. Three-dimensional printing orthopedic implants combined with low-intensity whole-body vibration load repairs bone defect and contributes to osseointegration[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(12): 1870-1874.

Figures/Tables 3

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