Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (9): 1434-1440.doi: 10.3969/j.issn.2095-4344.1590

Previous Articles     Next Articles

Biological characteristics of stromal cell-derived factor-1/CXC chemokine receptor 4 signal axis

Wu Zhouling1, 2, Basheer Hamed Hamood AL-Shameri1, 2, Ban Guifei2, Chen Wenxia2   

  • Revised:2018-11-30 Online:2019-03-28 Published:2019-03-28
  • Contact: Chen Wenxia, PhD, Professor, Department of Operative Dentistry and Endodontology, Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • About author:Wu Zhouling, Master candidate, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, School of Stomatology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; Department of Operative Dentistry and Endodontology, Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81560183 (to CWX)

Abstract:

BACKGROUND: Nowadays, stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signal axis has been used extensively because of its biological effects and particularly a great progress has been achieved in the mechanism of SDF-1/CXCR4 signal axis as well as in its use for tissue regeneration.
OBJECTIVE: To summarize the factors affecting the regulation of SDF-1 and CXCR4 and to review the research progress in the biological characteristics of SDF-1/CXCR4 signal axis.
METHODS: The first author searched the PubMed, CNKI, WanFang and VIP databases for relevant articles published from January 1990 to August 2018. The keywords were “tissue engineering; cell homing; chemokine; regeneration; pulp regeneration; HIF-1; SDF-1; CXCL12; CXCR4; NOX-A12” in both Chinese and English.
RESULTS AND CONCLUSION: Hypoxia-inducible factor-1 plays a key role in the regulation of SDF-1, and there are multiple factors which can affect the expression of CXCR4. SDF-1/CXCR4 signal axis formed by the combination of SDF-1 and CXCR4 plays an important biological role in various physiological and pathological processes. Blocking SDF-1 is used to inhibit the pathogenic effect of the SDF-1/CXCR4 signal axis for therapeutic purposes, while increasing SDF-1 can strengthen the SDF-1/CXCR4 signal axis and enhance the ability of chemotactic endogenous cell homing for tissue regeneration. To further illustrate the mechanism of the SDF-1/CXCR4 signal axis, we upregulate or downregulate the expression of SDF-1 or CXCR4 by exogenous means to influence the biological function of the signal axis, and thus provide theoretical basis for optimizing clinical treatment strategies, and developing the biological function of the signal axis for human health benefits.


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Tissue Engineering, Hypoxia-Inducible Factor 1, Dental Pulp, Chemokine CXCL12

CLC Number: