Basic research and clinical application of dental pulp stem cells: a bibliometric and visual analysis

doi:10.3969/j.issn.2095-4344.0636

Abstract

Abstract:

BACKGROUND: Dental pulp stem cells have the advantages of abundant sources, convenient collection, and low immunogenicity, but no ethical dispute. Meanwhile, dental pulp stem cells have strong proliferative capacity, self-renewal ability and multi-directional differentiation potential, which have broad application prospects in pulp regeneration and dental restoration.
OBJECTIVE: To conduct a statistical and visual analysis of literatures related to dental pulp stem cells.
METHODS: The keyword of “dental pulp stem cells” in English and Chinese was used by the first author to retrieve relevant articles published from 2003 to 2018 in SCI, CNKI databases, Clinicaltrials.gov, and China patent database, respectively. These relevant literatures were statistically analyzed through the built-in analysis function and the drawing function of Excel software in terms of time distribution, country, regional distribution, organization
distribution, publication distribution and document type distribution.
RESULTS AND CONCLUSION: The bibliometric and visual analysis for literatures addressing dental pulp stem cells published from 2003 to 2018 was performed by retrieval of the SCI, CNKI, Clinicaltrials.gov, and China patent database. This multi-aspect analysis on research trends in this field may provide valuable reference for relevant experts and researchers to further study hot topics in the field and select proper journals for paper submission.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Dental Pulp, Stem Cells, Tissue Engineering

CLC Number:

R394.2

Yan Xue-chuan, Su Yu-cheng. Basic research and clinical application of dental pulp stem cells: a bibliometric and visual analysis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(29): 4749-4756.

Figures/Tables 10

References

[1] Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97(25):13625-13630.

[2] Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-317.

[3] Atari M, Barajas M, Hernández-Alfaro F, et al. Isolation of pluripotent stem cells from human third molar dental pulp. Histol Histopathol. 2011;26(8):1057-1070.

[4] Oshima M, Mizuno M, Imamura A, et al. Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy. PLoS One. 2011; 6(7):e21531.

[5] Kerkis I, Ambrosio CE, Kerkis A, et al. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic. J Transl Med. 2008;6:35.

[6] Gandia C, Armiñan A, García-Verdugo JM, et al. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells. 2008;26(3):638-645.

[7] Yang R, Chen M, Lee CH, et al. Clones of ectopic stem cells in the regeneration of muscle defects in vivo. PLoS One. 2010; 5(10):e13547.

[8] Wang Z, Pan J, Wright JT, et al. Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod. 2010;36(5):820-825.

[9] 王洁,刘加强,房兵.牙髓干细胞在组织工程中的研究进展[J].口腔颌面修复学志, 2013,14(3):183-186.

[10] Piva E, Silva AF, Nör JE. Functionalized scaffolds to control dental pulp stem cell fate.J Endod. 2014;40(4 Suppl):S33-40.

[11] Takebe Y, Tatehara S, Fukushima T, et al. Cryopreservation Method for the Effective Collection of Dental Pulp Stem Cells. Tissue Eng Part C Methods. 2017;23(5):251-261.

[12] Albuquerque MT, Valera MC, Nakashima M, et al. Tissue-engineering-based strategies for regenerative endodontics. J Dent Res. 2014;93(12):1222-1231.

[13] Shi S, Zhou J, Shi Y, et al. Role of bone marrow-derived progenitor cells in the maintenance and regeneration of dental mesenchymal tissues. J Cell Physiol. 2011;226(8): 2081-2090.

[14] Liu Y, Jing H, Kou X, et al. PD-1 is required to maintain stem cell properties in human dental pulp stem cells. Cell Death Differ. 2018. doi: 10.1038/s41418-018-0077-8.

[15] Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009; 88(9):792-806.

[16] Sonoyama W, Liu Y, Yamaza T, Tuan RS, et al. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod. 2008;34(2):166-171.

[17] Arthur A, Rychkov G, Shi S, et al. Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells. 2008; 26(7):1787-1795.

[18] Huang GT, Sonoyama W, Liu Y, et al. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod. 2008;34(6):645-651.

[19] Cordeiro MM, Dong Z, Kaneko T, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34(8):962-969.

[20] Huang GT, Yamaza T, Shea LD, et al. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A. 2010;16(2):605-615.

[21] d'Aquino R, De Rosa A, Lanza V, et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater. 2009 12;18:75-83.

[22] Sakai K1, Yamamoto A, Matsubara K, et al. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. J Clin Invest. 2012;122(1): 80-90.

[23] Gandia C, Armiñan A, García-Verdugo JM, et al. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells. 2008;26(3):638-645.

[24] Prescott RS, Alsanea R, Fayad MI, et al. In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod. 2008;34(4): 421-426.