Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (29): 4721-4728.doi: 10.3969/j.issn.2095-4344.0632

Previous Articles     Next Articles

Premature senescence of mesenchymal stem cells: causes and preventive measures

Zhou Long1, He Fan2, Wang Lei1   

  1. 1Department of Orthopaedics, the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Science and Technology Town Hospital), Suzhou 215153, Jiangsu Province, China; 2Orthopaedic Institute, Soochow University, Suzhou 215007, Jiangsu Province, China
  • Revised:2018-07-16 Online:2018-10-18 Published:2018-10-18
  • Contact: Wang Lei, Associate chief physician, Department of Orthopaedics, the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Science and Technology Town Hospital), Suzhou 215153, Jiangsu Province, China
  • About author:Zhou Long, Master, Physician, Department of Orthopaedics, the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Science and Technology Town Hospital), Suzhou 215153, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31570978; the National Natural Science Foundation of China for the Youth, No. 51203194

Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) have strong self-renewal and multi-directional differentiation potential, which have been widely applied in the tissue engineering and regenerative medicine. However, it is inevitable to face the aging of MSCs during in vitro amplification.
OBJECTIVE: To elucidate the characteristics and causes of premature senescence of MSCs, and to summarize the measures to prevent the aging of MSCs in recent years, so as to explore a safe and effective method for early interventions that can delay the aging process.
METHODS: A computer-based search of CNKI and PubMed was performed to retrieve relevant articles published from 1988 to 2017. The key words were “mesenchymal stem cells; senescence; prevent; bone tissue engineering” in Chinese and English, respectively. Totally 109 eligible were included in the result analysis.
RESULTS AND CONCLUSION: Telomere shortening and oxidative stress make MSCs senescent. Growth factors, antioxidants, oxygen content and the extracellular matrix can significantly promote the proliferation of MSCs, and delay the cell aging. However, the specific mechanism is still unclear, which is worth further investigations.

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Mesenchymal Stem Cells, Aging, Tissue Engineering

CLC Number: