Tissue-engineered skin substitutes: a prospect evaluation from the aspects of morphology and function

doi:10.3969/j.issn.2095-4344.2017.16.024

Abstract

Abstract:

BACKGROUND: Tissue engineering is a booming subject in recent years, involving skin, cornea, bone, cartilage, tendon and etc. Noticeably, tissue-engineered skin is an issue of concern, which provides an alluring prospect for the repair of skin defects.
OBJECTIVE: To overview the latest research progress of tissue-engineered skin.
METHODS: A computer-based research of Medline database from 1996 to 2017 was performed, with the English keywords of “epidermis, dermis, tissue engineered skin”. The latest research status of tissue-engineered skin was summarized in views of epidermal and dermal substitutes, followed by exploring the problems and prospects of tissue-engineered skin.
RESULTS AND CONCLUSION: A total of 65 literatures were included. Complex skin substitutes include epidermis and dermis, in which hair follicles, sweat glands, sebaceous glands and other cutaneous appendages are absent. Therefore, how to solve above problems is a hotspot issue and major trend in tissue-engineered skin. Tissue-engineered skin aims to construct permanent skin substitutes containing melanocytes and Langerhans cells rapidly. Since the current tissue-engineered skin substitutes can completely replace skin tissues neither in morphology nor in function, in-depth studies are expected in the near future.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Biocompatible Materials, Skin

CLC Number:

R318

Wang Xiao-jing, Wang Guo-wei, Hui Guang-yan, Zhao Yi-min. Tissue-engineered skin substitutes: a prospect evaluation from the aspects of morphology and function[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(16): 2600-2605.

Figures/Tables 1

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