Preparation and characterization of a new kind of firm/soft adjusted poly(D,L-lactic acid)-polyurethane

doi:10.3969/j.issn.2095-4344.2013.25.017

Abstract

Abstract:

BACKGROUND: Biodegradable polyurethane is a focus in the field of biomedical materials. Poly(D,L-lactic acid)-polyurethane has a broad prospect in the biomedical field.
OBJECTIVE: To prepare a new poly(D,L-lactic acid)-polyurethane based on the molecular designing, using D,L-lactide, 1,6-hexamethylene diisocyanate, 1,4-butanediol and 1,4-butanediamine.
METHODS: The hydroxy-terminated poly(D,L-lactic acid) was synthesized by melt polymerization, and then1,6-hexamethylene diisocyanate was added as a crosslinker to produce poly(D,L-lactic acid)-polyurethane. These products were characterized by Fourier transform infrared spectrometry, nuclear magnetic resonance spectrometer, thermogravimetry/differential thermal analyzer and Instron 1121 universal tester to explore the structures and performance.
RESULTS AND CONCLUSION: The chemical structure of the products was consistent with the expected molecular structure. To adjust the proportion of reactants, we realized the control of the firm/soft transition degree (from 472% to 112% of the elongation at break) and firm/soft transition temperature (from 36.33 ℃ to 44.04 ℃ of the glass transition temperature). These findings indicate that the biodegradable poly(D,L-lactic acid)- polyurethane has thermosensitive effect, and its elongation at break and glass transition temperature can be controlled, which is the application foundation in the field of biomedical engineering.

Key words: biomaterials, material mechanics and surface modification, hermosensitive, polyurethane, poly(D,L-lactic acid), isocyanate, elongation at break, glass transition temperature, biomedical engineering, provincial grants-supported paper

CLC Number:

R318

Xu Jian, Peng Kun, Gan Xiao-ling,Wang Yi-zheng, Duan Qiao-ling, Ruan Chang-shun, Sun Jiao-xia. Preparation and characterization of a new kind of firm/soft adjusted poly(D,L-lactic acid)-polyurethane [J]. Chinese Journal of Tissue Engineering Research, 2013, 17(25): 4684-4691.

Figures/Tables 11

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