Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (1): 82-86.doi: 10.3969/j.issn.2095-4344.2017.01.015

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Umbilical cord mesenchymal stem cells combined with bone marrow stem cells for treatment of lower limb ischemia

Du Jun-wen, Wu Tao, Zhang Kun, Su Bai-yu, Lu Cai-ping, Wang Wei-chao, Lei Lin, Guo Jing-xia   

  1. First Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, China
  • Online:2017-01-08 Published:2017-03-15
  • Contact: Wang Wei-chao, Master, First Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, China
  • About author:Du Jun-wen, Master, Associate chief physician, First Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, China

Abstract:

BACKGROUND: Bone marrow stem cell transplantation has made great progress in the treatment of ischemic disease of the lower limbs. But for the senile patients, the therapeutic outcomes are greatly influenced by few bone marrow stem cells, difficulty in cell collection, and low differentiation ability.
OBJECTIVE: To study the clinical efficacy of umbilical cord mesenchymal stem cells combined with bone marrow stem cells in the treatment of lower limb ischemia.
METHODS: Forty-seven patients with lower limb ischemia treated with stem cell transplantation in the First Hospital of Shijiazhuang from March 2012 to November 2015 were assigned into either observation group (n=23; transplantation of umbilical cord mesenchymal stem cells combined with bone marrow stem cells) or control group (n=24; bone marrow stem cell transplantation).
RESULTS AND CONCLUSION: The total effective rate in the observation group was significantly higher than that of the control group (P=0.039). The skin temperature, percutaneous oxygen branch pressure and ankle brachial index in the observation group were significantly higher than those in the control group (P < 0.05). Scores on limb pain, limb coldness and intermittent claudication in the observation group were significantly lower than those in the control group (P< 0.05). It can be seen that the transplantation of umbilical cord mesenchymal stem cells combined with bone marrow stem cells have better clinical effects on lower limb ischemia stem than single use of bone marrow stem cells, as the combined transplantation can be more effective to relieve clinical symptoms, such as pain and sense of coldness, by improving limb skin temperature, transcutaneous oxygen partial pressure and ankle brachial index.

 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Lower Extremity, Ischemia, Mesenchymal Stem Cell Transplantation, Umbilical Cord, Bone Marrow, Tissue Engineering

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