Icariin promotes the osteogenic differentiation of mesenchymal stem cells: a good candidate for bone defect repair

doi:10.3969/j.issn.2095-4344.2016.50.021

Abstract

Abstract:

BACKGROUND: Recent studies have shown that icariin is a good bone-inducing factor that can promote the osteogenic differentiation of mesenchymal stem cells, providing a new hope for the treatment of bone defects.
OBJECTIVE: To review research achievements in pharmacological effects of icariin effects on bone tissue metabolism as well as its effect to promote osteogenic differentiation of mesenchymal stem cells.
METHODS: The first author retrieved CNKI and PubMed databases for relevant Chinese and English literatures using keywords of “icariin, stem cell, osteogenesis”, respectively. Articles regarding icariin, stem cells, osteogenesis were included, and repetitive studies were excluded. Totally 754 articles were retrieved initially. In accordance with inclusion and exclusion criteria, 41 articles were included in result analysis.
RESULTS AND CONCLUSION: As the main ingredient of Herba epimedii, icariin functions as a good osteogenetic growth factor to promote the osteogenic differentiation of bone marrow mesenchymal stem cells. In recent years, icariin has been shown to promote adipose-, umbilical cord-, and periodontal ligament tissue-derived mesenchymal stem cells to differentiate into osteoblasts. But such studies are less reported. Until now, mesenchymal stem cells still exhibit unsatisfactory osteogenic ability in in vivo experiments. Given this, osteogenetic growth factors contribute to the osteogenic differentiation of mesenchymal stem cells. Therefore, the use of icariin is expected to provide a good strategy for bone defect repair.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Tissue Engineering, Bone Marrow

CLC Number:

R318

Chen Zhen-dong, Gao Hui, Xu Fang-tian . Icariin promotes the osteogenic differentiation of mesenchymal stem cells: a good candidate for bone defect repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(50): 7594-7600.

Figures/Tables 1

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