Methods of bone marrow mesenchymal stem cells differentiating into hepatocytes and the underlying mechanisms

doi:10.3969/j.issn.2095-4344.2016.50.020

Abstract

Abstract:

BACKGROUND: A number of studies have shown that there are many inducible methods by which bone marrow mesenchymal stem cells can differentiate into hepatocytes, but the specific molecular mechanism is unclear yet.
OBJECTIVE: To review the programs and underlying mechanisms by which bone marrow mesenchymal stem cells differentiate into hepatocytes.
METHODS: A computer-based online search of CNKI, VIP, WanFang and PubMed databases was performed to retrieve articles about directional differentiation of bone marrow mesenchymal stem cells into hepatocytes published between 2004 and 2015. The key words were “hepatocyte (-like) cells, bone marrow mesenchymal stem cells, differentiation” in Chinese and English, respectively. Finally, 62 articles were included in result analysis.
RESULTS AND CONCLUSION: There are many programs for hepatic differentiation of bone marrow mesenchymal stem cells, but the specific molecular mechanism is still unclear. Many studies mainly focus on Notch signaling pathway, Wnt/β-catenin signaling pathway, P38 signal pathway, miR-122 and effect of calcium ions. Bone marrow mesenchymal stem cells that can be induced to differentiate into mature hepatocytes provide an ideal cellular source for hepatocyte transplantation and artificial liver, which is proposed to be a new strategy for clinical treatment of end-stage liver disease.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Bone Marrow, Mesenchymal Stem Cells, Cell Differentiation, Hepatocytes, Tissue Engineering

CLC Number:

R318

Xie Shu-cai, Zhang Jian-quan, Jiang Xi-li, Zhou Shuai. Methods of bone marrow mesenchymal stem cells differentiating into hepatocytes and the underlying mechanisms[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(50): 7586-7593.

Figures/Tables 1

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