Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (30): 4532-4538.doi: 10.3969/j.issn.2095-4344.2016.30.018

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Sustained-release carriers of insulin: applications and existing problems

Chen Guo-chang, Gao Hong   

  1. Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
  • Received:2016-05-16 Online:2016-07-15 Published:2016-07-15
  • About author:Chen Guo-chang, Master, Associate chief physician, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Abstract:

BACKGROUND: Sustained-release carriers of insulin shaped as microspheres made of different biomaterials have become an issue of concern.
OBJECTIVE: To summarize the carrier materials and methods to prepare sustained-release microspheres of insulin.
METHODS: Wanfang and PubMed databases were retrieved by computer for articles related to sustained-release carriers of insulin published from 1997 to 2015. The search terms were “insulin, controlled-release carrier, biomaterials” in Chinese and English, respectively.
RESULTS AND CONCLUSION: Natural biodegradable polymer materials are preferred to prepare sustained-release microspheres of insulin, including gelatin, alginate, chitosan and its derivatives. These natural materials have good biocompatibility, degradability, film-forming and microsphere-forming abilities. Synthetic biodegradable polymer materials as carrier materials can promote drug stability and effective utilization, and realize targeted drug delivery. According to different physicochemical properties of materials, sustained-release carriers of insulin that meet different requirements can be prepared using emulsion-chemical crosslinking, spray drying and solvent evaporation methods. This review provides new insight into the development of stable drug carriers.

Key words: Insulin, Delayed-Action Preparations, Tissue Engineering

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