Percutaneous balloon angioplasty combined with injectable coral artificial bone repairs femoral head necrosis

doi:10.3969/j.issn.2095-4344.2016.25.006

Abstract

Abstract:

BACKGROUND: There are many methods for the treatment of femoral head necrosis, such as core decompression, bone graft, arthroplasty and joint replacement, and each of which has its own shortcomings. So, percutaneous balloon angioplasty combined with coral artificial bone provides a new attempt for the treatment of femoral head necrosis.

OBJECTIVE: To observe the effect of percutaneous balloon angioplasty combined with coral artificial bone on femoral head necrosis repair.

METHODS: Twenty-four Duroc piglets were enrolled to establish bilateral femoral head necrosis models by liquid nitrogen freezing method. Then, model piglets were randomly treated with percutaneous balloon angioplasty combined with injectable coral artificial bone (experimental group) or bone cement (control group) on one affected side, and meanwhile, given no treatment on the contralateral side (blank control group). At 2, 4, 8 and 16 weeks after surgery, X-ray examination, biomechanical test and histological detection were conducted.

RESULTS AND CONCLUSION: X-ray showed that at 16 weeks after surgery, numerous new bones could be found in the experimental group and there was a fuzzy boundary between the artificial bone and surrounding tissues; no new bone formed in the control group, and the boundary was clear; in the blank control group, the surface of the femoral head collapsed, and bone trabeculae arranged disorderly, which were seriously destroyed. And in the histological detection at 16 weeks after surgery, there were numerous bone trabecula and osteoblasts around the coral bone in the experimental group, and the coral artificial bone almost dissolved; in the control group, bone cement was in an irregular shape and no bone trabecula formed; in the blank control group, bone trabecula were damaged in the collapsed area, whose structure was in disorder. Additionally, biomechanical changes in the experimental group were significantly better than those in the other two groups at different time points after surgery (P < 0.05). In conclusion, percutaneous balloon angioplasty combined with coral artificial bone can repair femoral head necrosis by promoting new bone formation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Femur Head Necrosis, Stem Cells, Tissue Engineering

CLC Number:

R318

Zhu Kang-hua, Meng Zhi-bin, Huang Tao, Tan Hai-tao, Sun Bo, Pang Xue-yi. Percutaneous balloon angioplasty combined with injectable coral artificial bone repairs femoral head necrosis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(25): 3687-3692.

Figures/Tables 4

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