Binding capacity of nano-hydroxyapatite/polyamide composite material on the interface of artificial humeral head

doi:10.3969/j.issn.2095-4344.2015.30.002

Abstract

Abstract:

BACKGROUND: Nano-hydroxyapatite/polyamide 66 is a new nanobionic composite material and has good biocompatibility and bone conduction, but after implantation, whether the composite material can bind to vertebral bone interface and whether it is safe in clinical use still need further studies.

OBJECTIVE: To observe the ability of nano-hydroxyapatite/polyamide composite binding to the interface of artificial humeral head.

METHODS: The rabbits were randomly divided into two groups: composite group was implanted with nano-hydroxyapatite/polyamide composites; control group implanted with autologous bone. After the replacement, rabbit bone marrow mesenchymal stem cells were subjected to primary culture, and then the cells were co-cultured with the composite material.

RESULTS AND CONCLUSION: At 24 hours after culture, bone marrow mesenchymal stem cells grew well on the composite materials. The cell adhesion rate was significantly higher in the composite group than the control group at 1 and 4 hours after culture (P < 0.05). After co-culture 4.5, 5.5, 6.5 hours, the absorbance value of cells in the composite group was higher than that in the control group (P < 0.05). At 24 weeks after replacement, changing ranges in the proportions of bone tissue and fibrous layers on the implant surface as well as coverage rate in the composite group were the highest (P < 0.05). These findings indicate that the nano-hydroxyapatite/ polyamide composite implant has a certain binding capacity, which can make a good interface osseointegration.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Humerus, Stem Cells

CLC Number:

R318

Liu Yong, Huang Wei . Binding capacity of nano-hydroxyapatite/polyamide composite material on the interface of artificial humeral head[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(30): 4764-4768.

Figures/Tables 4

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