Chinese medicine intervention for steroid-induced necrosis of the femoral head: from basic study to clinical application

doi:10.3969/j.issn.2095-4344.2015.29.026

Abstract

Abstract:

BACKGROUND: Chinese herbal medicine for treatment of steroid-induced necrosis of the femoral head has been shown to be effective, but its mechanism remains controversial.OBJECTIVE: To retrieve and summarize the mechanism of Chinese herbal medicine for steroid-induced necrosis of the femoral head in recent 10 years.METHODS: We retrieved articles addressing the mechanism of Chinese herbal medicine for intervention of steroid-induced necrosis of the femoral head in China National Knowledge Infrastructure published from January 2005 to December 2014. The key words were femur head necrosis, hormones, drugs, and Chinese herbal. According to inclusion and exclusion criteria, 23 articles were selected for discussion.
RESULTS AND CONCLUSION: Studies concerning the mechanism of Chinese medicine for steroid-induced necrosis of the femoral head mainly focus on lowering blood lipid and anticoagulation, improving blood rheology, reducing intraosseous pressure, promoting angiogenesis and inhibiting apoptosis, as well as cytokines and related factors. This study mainly concerns classical formulae, empirical prescription and various Chinese patent medicines, but does not address differentiation of symptoms and signs for classification of syndrome, diagnosis and treatment based on an overall analysis of the illness and the patient’s condition, targeted rule of treatment, and prescription drugs.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: femur head necrosis, hormones, drugs, Chinese herbal

CLC Number:

R318

Zhou Zheng-xin. Chinese medicine intervention for steroid-induced necrosis of the femoral head: from basic study to clinical application[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(29): 4726-4730.

Figures/Tables 1

References

[1] Jones JP Jr.lntravascular cosgulation and osteonecrosis. Clin Orthop Relat Res. 1992;(277):41-53.

[2] 尹华,章建华,李昌煌,等.芪参健骨颗粒对股骨头坏死大鼠脂代谢的影响[J].中国实验方剂学杂志,2012,18(22):248-251.

[3] 王荣田,林诗富,万蓉,等.不同治法方药对激素性股骨头坏死鸡血脂、血黏度、凝血及纤溶功能的影响[J].中医正骨,2013,25(3): 21-30.

[4] 曾荣香,徐志毅,雷凯君,等.补阳还五汤对激素性股骨头坏死大鼠血液流变学、凝血及纤溶的影响[J].中华中医药学刊,2012,30(8): 1852-1854.

[5] 段卫峰,高书图,刘又文,等.股骨头坏死愈胶囊对兔激素性股骨头坏死血流变学影响的实验研究[J].陕西中医,2013,34(1):99-103.

[6] 卞敬琦,冯月男,张瑶,等.活骨丹胶囊对大鼠血液流变学及部分生化指标的影响[J].中国实验方剂学杂志,2013,19(13):250-253.

[7] 赵家胜,瞿群威,胡永均,等.针刀减压对股骨头缺血性坏死患者骨内压及氧自山基含量的影响[J].上海针灸杂志,2012,31(9): 667-669.

[8] 刘泽霖,徐西林,张晓峰,等.活骨注射液治疗股骨头缺血性坏死组织形态学实验研究[J].中医药学报,2013,41(2):30-32.

[9] 江树连,朱磊,周正新,等.骨蚀宁胶囊治疗股骨头坏死的实验研究[J].中医药临床杂志,2012,24(12):1149-1150.

[10] Suzuki O,Bishop AT,Sunagawa T.VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery. 2004;24(1): 85-91.

[11] Radke S,Battmann A,Jatzke S. Expression of the angiomatrix and angiogenic proteinsCYR61,CTGF,and VEGF in osteonecrosis of the femoral head. J Othop Res. 2006;24 (5): 945-952.

[12] 赵万军,杨武民,杨贺杰,等.克骨汤对兔激素性股骨头坏死血管内皮生长因子表达影响的实验研究[J].全科医学临床与教育, 2013, 11(4):373-376.

[13] 段卫峰,高书图,刘又文.股骨头坏死愈胶囊对兔激素性股骨头坏死血管内皮生长因子表达影响的实验研究[J].世界中西医结合杂志,2012,7(11):944-947.

[14] 孔祥英,田能,王荣田,等.活骨II方加不同引经药对股骨头坏死兔股骨头内血管内皮生长因子表达的影响[J].中国实验方剂学杂志, 2012,18(8):237-241.

[15] 程少华,崔超,常巍,等.激素性股骨头缺血性坏死细胞凋亡的实验研究[J].中华实用诊断与治疗杂志,2010,24(4):368-370.

[16] Kerachian MA,Cournoyer D, Harvey EJ,et al. New insights into the pathogenesis of glucocorticoid-induced avascular necrosis:microarray analysis of gene expression in a rat model. Arthritis Res Ther.2010;12(3):2-12.

[17] 杨俊兴,徐传毅,李厂杰,等.非创伤性股骨头坏死的骨细胞凋亡研究[J].实用医学杂志,2006,22(18):2127-2129.

[18] 李洪涛,于雪峰,程永志,等.骨蚀灵对激素性股骨头坏死早期干预作用的研究[J].中国中医药科技,2010,17(3):228.

[19] 师彬,孙国栋,王平,等.仙鹿活骨丸对激素性股骨头坏死细胞凋亡影响的实验研究[J].上海中医药杂志,2009,43(5):68-71.

[20] 吉万波,刘冠虹,刘锦涛,等.中药股密葆治疗大鼠激素性股骨头坏死的生物力学作用机理研究[J].中国中医骨伤科杂志, 2013, 21(9): 7-10.

[21] 李卫华,王晓,刘冰山,等.六味地黄丸预防激素性股骨头缺血性坏死的分子机制研究[J].中国修复重建外科杂志,2010,24(4): 446-451.

[22] 段瑞奇,刘文刚,区钰强,等.中药骨康诱导兔肝细胞色素CYP3A表达及抗激素性股骨头坏死实验研究[J].中医药导报, 2013, 19(7):10-13.

[23] 张弛,杨志伟,段小英.活血通络法治疗激素性股骨头坏死兔胰岛素样生长因子1的变化[J].中国组织工程研究,2012,16(52): 9787-9791.