Micro-inflammatory state and calcification

doi:10.3969/j.issn.2095-4344.2015.29.025

Abstract

Abstract:

BACKGROUND: In recent years, pathological calcification such as vascular calcification has been an active deposition of the mineralizer in the abnormal parts, can promote the occurrence and development of many diseases. Moreover, extensive studies believe that micro-inflammatory state is strongly associated with pathological calcification.

OBJECTIVE: To further summarize the relationship between micro-inflammatory state and calcification based on the relationship between inflammatory factor and calcification-related factors.

METHODS: A computer-based search of CNKI, Wanfang database and PubMed database from January 2000 to January 2015 was performed for articles addressing the relationship between micro-inflammatory state and calcification. The key words were “calcification, micro-inflammatory state, inflammatory factor” in Chinese and English.

RESULTS AND CONCLUTION: Micro-inflammatory state is a non-dominant inflammatory state, caused by an infection of non-pathogenic microorganisms, mainly for the elevated inflammatory protein, inflammatory cytokines in the systemic circulation. At present, pro-inflammatory cytokines interleukin-1, interleukin-6, interleukin-8, tumor necrosis factor-alpha and acute phase protein C reactive protein were considered as the objective and sensitive detection index of micro-inflammation state. A large number of studies have found that a slight elevation of interleukin-1, interleukin-6, interleukin-8, tumor necrosis factor-alpha and C reactive protein was positively correlated with calcification promoting factors, which illustrated that the micro-inflammatory state has the role of promoting the calcification.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Calcium, Interleukins, Tumor Necrosis Factor-alpha, Cytokines

CLC Number:

R318

Qin Chao-shi, Li Xiao-yan, Jiang Xue-jun, Feng Gao-ke. Micro-inflammatory state and calcification[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(29): 4721-4725.

Figures/Tables 1

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