Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (11): 1711-1716.doi: 10.3969/j.issn.2095-4344.1117

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Low-frequency pulsed electromagnetic field promotes neurologic function recovery after delayed repair of perioheral nerve injury in rats

Zhang Liqian1, Xu Chungui1, Li Ziyu1, Yao Fei1, Zha Xiaowei1, Qi Lei2, Jing Juehua1   

  1. (1Department of Orthopedics, the Second Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China; 2Department of Orthopedics, Pukou Hospital of Nanjing City, Nanjing 211800, Jiangsu Province, China)
  • Received:2018-11-28 Online:2019-04-18 Published:2019-04-18
  • Contact: Jing Juehua, Doctoral supervisor, Professor, Chief physician, Department of Orthopedics, the Second Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China
  • About author:Zhang Liqian, Master candidate, Department of Orthopedics, the Second Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China Xu Chungui, MD, Department of Orthopedics, the Second Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China Zhang Liqian and Xu Chungui contributed equally to this work.

Abstract:

BACKGROUND: Low-frequency pulsed electromagnetic fields can promote the immediate repair of peripheral nerve injury, but its effect on delayed repair is still unclear.
OBJECTIVE: To explore whether low-frequency pulsed electromagnetic fields can promote the recovery of neurologic function in rats after delayed repair of peripheral nerve injury.
METHODS: Sixty rats were used for constructing the model of peripheral nerve injury, and then the rat models were randomized into low-frequency pulsed electromagnetic field treatment and delayed repair groups, and another 30 rats were included in the sham operation group. The rats in the low-frequency pulsed electromagnetic field treatment group received low-frequency pulsed electromagnetic fields after sciatic nerve disconnection and delayed repair intervention. The delayed repair group received sciatic nerve disconnection and delayed repair intervention. The sham operation group only exposed the sciatic nerve without disconnection.
RESULTS AND CONCLUSION: The sciatic functional index in the low-frequency pulsed electromagnetic field treatment group was significantly higher than that in the delayed repair group. Western blot assay results showed that the expression levels of brain-derived neurotrophic factor and vascular endothelial growth factor in the sciatic nerve were significantly increased. Immunohistochemistry revealed that the number of sciatic nerve cells in the low-frequency pulsed electromagnetic field treatment group was significantly increased. In summary, low-frequency pulsed electromagnetic fields can promote neurologic function recovery after delayed repair of peripheral nerve injury in rats.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Electromagnetic Fields, Sciatic Nerve, Tissue Engineering

CLC Number: