Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (19): 3108-3116.doi: 10.3969/j.issn.2095-4344.2017.19.024
Chen Xiao, Ma Kun-long, Xu Hai-tao, Shao Gao-hai
Online:
2017-07-08
Published:
2017-08-10
Contact:
Shao Gao-hai, Master, Chief physician, Professor, Department of Orthopedics, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China
About author:
Chen Xiao, Studying for master’s degree, Department of Orthopedics, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China
CLC Number:
Chen Xiao, Ma Kun-long, Xu Hai-tao, Shao Gao-hai. Modified Stoppa approach versus Ilioinguinal approach for pelvic and/or acetabular fractures: a meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2017, 21(19): 3108-3116.
2.1 纳入文献的基线特征 通过计算机与手工检索,共得到753篇文献。阅读文献标题、摘要及全文后,共排除742篇,排除原因包括:①各数据库之间重复文献和重复发表文献454篇;②非临床研究、回顾性研究、队列研究、非随机分组研究、个案报道、综述等288篇;③数据不全的研究0篇。最终纳入11个RCT研究[29-39],其中9篇为中文文献[29-37],2篇为英文文献[38-39]。共计722例患者,其中试验组(改良Stoppa入路)359例患者,对照组(髂腹股沟入路)363例患者,纳入文献的基本情况见表1。 2.2 纳入文献的质量评价 采用“Cochrane协作网的偏倚风险评估标准”对纳入的11个研究进行质量评价[29-38],纳入研究各种偏倚所占比例见图2,纳入研究质量评价及风险评估见图3。 2.3 Meta分析结果 由于KunLong Ma文献中计量资料均采用均数及其范围表示,经过联系作者本人,从而获得相关指标的均数及其标准差,进行相关统计量合并。 2.3.1 手术时间 纳入研究中11篇进行了手术时间比 较[29-38],其异质性检验显示有显著统计学意义(P < 0.000 01,I2=85%),故采用随机效应模型进行统计量合并。结果示:改良stoppa入路与髂腹股沟入路2组手术时间相比较差异有非常显著性意义[MD=-46.32,95%CI(-57.84,-34.79),P < 0.000 01,见图4];通过检验评估纳入研究的发表偏倚,漏斗图结果显示无发表偏倚(见图5)。"
2.3.2 术中出血量 纳入研究中10篇进行了术中出血量比较[29-38],其异质性检验显示有统计学差异(P < 0.000 01,I2=99%),采用随机效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组术中出血量比较差异有显著性意义[MD=-113.66,95%CI(-166.03,-61.29),P < 0.000 1,见图6]。 2.3.3 术后并发症 纳入研究中有6篇报道了术后并发 症[29,33-34,37-39],其异质性检验有统计学差异(P=0.02,I2=62%),采用随机效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组术后总并发症相比较差异无显著性意义[RR=0.62,95%CI(0.27,1.44),P=0.27,见图7];对其进行亚组分析,各并发症指标异质性检验均差异无显著性意义(P > 0.05,I2 < 50%),均采用固定效应模型进行合并。其中5篇报道了切口感染,差异无显著性意义[RR=0.53,95%CI(0.18,1.51),P=0.23];4篇报道了神经损伤,差异无显著性意义[RR=0.1.71,95%CI(0.66,4.45),P=0.27];2篇报道了血管损伤,差异无显著性意义[RR=0.85,95%CI(0.21,3.54),P=0.83];2篇报道了髋关节炎发生率,差异无显著性意义[RR=0.88,95%CI(0.34,2.26),P=0.78];2篇报道了深静脉血栓发生率,差异无显著性意义[RR=0.60,95%CI(0.08,4.38),P=0.61];2篇报道了疝发生率,差异无显著性意义[RR=0.33,95%CI (0.04,3.08),P=0.33],详见图8。 2.3.4 住院时间 纳入研究中有2篇报道了住院时 间[36,38],其异质性检验无显著统计学意义(P=0.46,I2=0%),采用固定效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组住院时间相比较有统计学意义[MD=-1.71,95%CI(-3.01,-0.41),P=0.01,见图9]。 2.3.5 临床疗效 纳入研究中有7篇报道了临床疗 效[30-32,35-36,38-39],其异质性检验有显著统计学差异(P=0.02,I2=60%),采用随机效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组临床疗效相比较差异有显著性意义[RR=1.21,95%CI(1.03,1.42),P=0.02,见图10]。 2.3.6 切口长度 纳入研究中有2篇报道了手术切口长 度[36-37],其异质性检验有显著统计学差异(P < 0.000 01,I2=98%),采用随机效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组手术切口长度相比较有统计学意义[MD=-6.53,95%CI(-11.82,-1.24),P=0.02,见图11]。2.3.7 引流量 纳入研究中有2篇报道了伤口引流量[36,38],其异质性检验无统计学意义(P=0.94,I2=0%),采用固定效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组伤口引流量相比较差异有显著性意义[MD=-50.17,95%CI(-65.62,-34.72),P < 0.000 01,见图12]。 2.3.8 Matta评分 纳入研究中有4篇报道了Matta评 分[29,37-39],其异质性检验无统计学意义(P=0.46,I2=0%),采用固定效应模型进行统计量合并。改良stoppa入路与髂腹股沟入路2组Matta评分相比较差异无显著性意义[RR=1.07,95%CI(0.96,1.20),P=0.24,见图13]。"
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