Hydroxyapatite biocoating improves bone-implant interface and promotes osseointegration

doi:10.3969/j.issn.2095-4344.2016.38.003

Abstract

Abstract:

BACKGROUND: We have designed and manufactured a novel artificial cervical vertebra and intervertebral complex (ACVC) which combines the cervical titanium cage with the artificial cervical disc, and also developed the ACVC with a hydroxyapatite biocoating (ACVC-HA).
OBJECTIVE: To evaluate biomechanical properties of the joint system, and the role of HA coating in promoting osseointegration and long-term stability.
METHODS: Twenty-four goats were randomly divided into three groups and underwent the anterior C _2/3 and C_3/4 discectomy, and C₃ subtotal corpectomy, followed by ACVC implantation (group 1) and ACVC-HA implantation (group 2), and given no intervention (black control group), respectively. group. At 12 weeks after surgery, C _1-5 samples were collected to undergo biomechanical tests and histological staining.
RESULTS AND CONCLUSION: Prior to the fatigue test, compared with the blank control group, the range of motion and neural zone of groups 1 and 2 in the directions of flexion-extension and lateral bending showed no significant differences, but the above indicators were significantly increased in the direction of rotation (P < 0.05). Additionally, the stiffness in all three directions was significantly lower than that in the blank control group (P < 0.05). There were no significant differences in the range of motion and neural zone in all directions between groups 1 and 2. Similar results were found after the fatigue test. The histological staining showed that both two implants had good biocompatibility and abradability, but more new bone formed on the ACVC-HA. These results suggest that ACVC can effectively reconstruct the motor function of the cervical spine after decompression. Furthermore, HA coating can markedly improve bone-implant interface to promote osseointegration.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Arthroplasty, Replacement, Hydroxyapatites, Spinal Fusion, Tissue Engineering

CLC Number:

R318

Qin Jie1, Zhao Bo, Wang Dong, Dong Jun, Li Hao-peng, Guo Lei, Wang Shuang, He Xi-jing.

Hydroxyapatite biocoating improves bone-implant interface and promotes osseointegration

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(38): 5642-5649.

Figures/Tables 6

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