Vascular endothelial growth factor and bone morphogenetic protein in the bone tissue engineering

doi:10.3969/j.issn.2095-4344.2015.33.021

Abstract

Abstract:

BACKGROUND: Segmental bone defects resulting from osteoporotic fractures, trauma, congenital bone dysplasia and progressive bone disorder are very common, and bone tissue engineering provides a new approach to bone defect repair. Growth factors related to bone tissue engineering bone have been reported a lot and have achieved some results. How to mimick the natural timing of different growth factors with different bioactivities has become the current hotspot in bone repair.
OBJECTIVE: To review the new developments in vascular endothelial growth factor and bone morphogenetic protein in bone tissue engineering.
METHODS: The first author searched CNKI (1990/2015) and Medline database (1990/2015) for related articles using the key words of “osteogenic factors, angiogenic factors, tissue engineering bone, bone repair, vascularization, vascular endothelial growth factor, bone morphogenetic protein, sequential release, seed cells, cytoskeleton” in Chinese and English, respectively. Mechanism of action and research direction about vascular endothelial growth factor and bone morphogenetic protein were summarized.
RESULTS AND CONCLUSION: Totally 313 papers were searched initially, and finally 87 papers were enrolled in result analysis. The results show that different growth factors play different roles in bone repair. Vascularization and osteogenesis are the most important processes in bone repair. The osteogenic factors play an important role in maintaining bone structure and bone formation. The angiogenic factors can provide oxygen and nutrients for tissue growth, differentiation and functionalization. The combination of osteogenic and angiogenic factors has a better osteogenic effect than osteogenic or angiogenic factors used alone. However, the most important problem is how to control the exogenous osteogenesis and the release dosage of angiogenic factors in bone repair.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Stents, Vascular Endothelial Growth Factors

CLC Number:

R318

Ji Jing-tao, Hu Yong-cheng, Xia Qun, Miao Jun, Chen Xiao-peng, Fang Cheng. Vascular endothelial growth factor and bone morphogenetic protein in the bone tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(33): 5356-5363.

Figures/Tables 1

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