Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (43): 7047-7052.doi: 10.3969/j.issn.2095-4344.2014.43.027

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Holmium laser lithotripsy versus pneumatic lithotripsy for treatment of distal ureteral calculi: a meta-analysis

Ainiwaer Aierken, Wang Ling-ling, Zhong Shan, Zhou Tuo, Shan Dou-lian   

  1. Department of Urinary Surgery, Second People’s Hospital of Kashgar, Kashgar 844000, Xinjiang Uygur Autonomous Region, China
  • Received:2014-09-15 Online:2014-10-15 Published:2014-10-15
  • Contact: Shan Dou-lian, Chief physician, Department of Urinary Surgery, Second People’s Hospital of Kashgar, Kashgar 844000, Xinjiang Uygur Autonomous Region, China
  • About author:Ainiwaer Aierken, Master, Physician, Department of Urinary Surgery, Second People’s Hospital of Kashgar, Kashgar 844000, Xinjiang Uygur Autonomous Region, China

Abstract:

BACKGROUND: Pneumatic lithotripsy and holmium laser lithotripsy for distal ureteral calculi have their own advantages and disadvantages in efficacy and complications, but both of them are currently better treatments.
OBJECTIVE: To compare the efficacy and safety of holmium laser lithotripsy and pneumatic lithotripsy for the treatment of distal ureteral calculi through a meta analysis.
METHODS: A online search of China Biological Medicine disk, PubMed, Cochrane Library, Springerlink, Medline, and Embase databases was performed from March 1999 to December 2013. A manual retrieval of relevant journals was also done for clinical trials about holmium laser lithotripsy and pneumatic lithotripsy for treatment of distal ureteral calculi. RevMan 5.1.5 software (Cachrane Library) was used for meta analysis. The following indexes were used to compare the results: mean operative time, early stone free rate, stone migration rate, ureteral perforation rate, postoperative hematuria rate and retaining double-J catheter rate.
RESULTS AND CONCLUSION: Four prospective studies (a total of 275 patients) were enrolled, and there were 140 cases in the group of holmium laser lithotripsy and 133 cases in the pneumatic Lithotripsy group. Holmium laser lithotripsy conveyed significant benefits compared with pneumatic lithotripsy in mean operative time [WMD=-16.38, 95%CI (-20.29, -12.47), P < 0.000 01], stone migration incidence [OR=0.25, 95%CI (0.10, 0.63), P=0.003], retaining double-J catheter rate [OR=0.44, 95%CI (0.25, 0.78), P=0.004], while early stone free rate, postoperative hematuria rate and ureteral perforation rate had no significant changes between the two groups. Compared with pneumatic lithotripsy, holmium laser lithotripsy can shorten mean operative time and reduce the stone migration rate. Because of the lack of prospective studies and small sample size, large-sized randomized 
controlled studies are urgently needed to provide evidence.


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


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Key words: ureteral calculi, laser therapy, meta-analysis

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