Osteogenesis detection for beta-tricalcium phosphate/poly(lactic-co-glycolic acid)/isoniazid/levofloxacin slow-release materials

doi:10.3969/j.issn.2095-4344.2013.03.001

Abstract

Abstract:

BACKGROUND: The degradation rate and strength of poly(lactic-co-glycolic acid) (PLGA) can be regulated by the addition of beta-tricalcium phosphate (β-TPC).
OBJECTIVE: To test the effect of β-TPC/PLGA/isoniazid (INH)/levofloxacin (LVFX) composite on the repair of femoral condyle bone defects in rabbits.
METHODS: Thirty New Zealand rabbits were used for preparing a rabbit model of bone defects with the diameter of 5 mm and the depth of 10 mm. The rabbits were randomly divided into three groups: group 1, group 2 and group 3. The former two groups were implanted with β-TPC/PLGA and β-TPC/PLGA/INH/LVFX, respectively. The group 3 was untreated as the blank control group. The repair effects of each group were detected by imaging, gross specimen and histological examination.
RESULTS AND CONCLUSION: At week 12 after treatment, bone defects in the two experimental groups were both radiographically repaired, and there was no significant difference between these two groups in the ratio of new bone area to bone defects area (P > 0.05). The blank control group failed to restore bone defects. These results suggest that the PLGA/TCP/INH/LVFX material can effectively repair femoral condyle bone defects in rabbits.

Key words: biomaterials, tissue-engineered bone materials, poly(lactic-co-glycolic acid, beta-tricalcium phosphate, bone defects, bone tuberculosis, bone tissue engineering, National Natural Science Foundation of China, biomaterial photographs-containing paper

CLC Number:

R318

Cui Xu, Ma Yuan-zheng, Li Da-wei, Xue Hai-bin. Osteogenesis detection for beta-tricalcium phosphate/poly(lactic-co-glycolic acid)/isoniazid/levofloxacin slow-release materials[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(3): 381-386.

Figures/Tables 3

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