Abstract:

BACKGROUND: Patients with serious osteoporosis have more bleeding volume than those without osteoporosis during cardiac surgery with cardiopulmonary bypass.
OBJECTIVE: To study the efficacy of oxidized regenerated cellulose on reducing post-cardiopulmonary bypass sternal bleeding and preventing sternal infection in patients with severe osteoporosis．
METHODS: Eighty-four cases of severe osteoporosis undergoing open heart surgery were randomly divided into oxidized regenerated cellulose group and control group. The sternal wound and bone marrow cavity of the oxidized regenerated cellulose group was filled with oxidized regenerated cellulose, and that of the control group was with medical bone wax. Drainage volume at the first postoperative day, total drainage volume, time of draining tube, blood transfusion volume, suture removal time, duration of persistent fever, average hospital staying, postoperative sternal wound healing were recorded and observed, and all the patients were follow-up for 6 months.
RESULTS AND CONCLUSION: The comparison between two groups in the drainage volume at the first postoperative day, the total drainage volume, time of draining tube, the volume of blood transfusion and average hospital staying was significantly different (P < 0.05). During the follow-up, there was no case of discharging the foreign body from sternal wound in the oxidized regenerated cellulose group and 3 cases of discharging bone wax in the control group. Oxidized regenerated cellulose can be used in reducing bleeding and preventing sternal infection in patients with severe sternal osteoporosis after cardiopulmonary bypass. The short- and long-term efficacy is reliable.