Trends in global research on bone and joint tuberculosis:
bibliometrics and visual analysis

doi:10.3969/j.issn.2095-4344.2462

Abstract

Abstract:

BACKGROUND: Herein, we investigate the research status and development trend of bone and joint tuberculosis in recent years, and deepen the understanding of bone and joint tuberculosis, which may provide clues for early diagnosis and timely treatment of bone and joint tuberculosis.

OBJECTIVE: To analyze the global research status and development trend of bone and joint tuberculosis.

METHODS: Web of science was searched for publications addressing bone and joint tuberculosis from 1994 to 2018. Retrieval data were statistically analyzed by bibliometrics method. The Vos viewer software was used for the visualization transformation of co-occurrence analysis and co-production analysis. The current situation and trend of bone and joint tuberculosis in recent years were then analyzed.

RESULTS AND CONCLUSION: A total of 2 761 studies were included in the study, indicating a global increase in the number of publications year by year. The United States has the largest number of publications, highest times cited and H index. China ranks 3^rdin global literature publication, 12^th in total citations and 13^th in the H index. Publications in PloS One, Journal of Immunology and Infection and Immunity rank top three. The University of Central South, the University of Cape Town and University College London are the top three institutions in terms of the number of publications. Studies on bone and joint tuberculosis could fall into six categories: early diagnosis and treatment of tuberculosis, treatment and complications of spinal tuberculosis, characteristics of pathogenesis in bone and joint tuberculosis, molecular detection of bone and joint tuberculosis, cytology of bone and joint tuberculosis, and relationship between osteoarthritis tuberculosis and immunology. GeneXpert MTB/RIF may become the hot research topic. The trend of global research on bone and joint tuberculosis indicates that literature regarding bone and joint tuberculosis is increasing, and the United States is the largest contributor. Current studies have focused on the diagnosis and treatment of bone and joint tuberculosis, and the relationship between GeneXpert MTB/RIF and bone and joint tuberculosis may become the hot research topic.

Key words: bone and joint, tuberculosis, bibliometrics, visualization, co-occurrence analysis, co-author analysis, National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province

CLC Number:

He Xiaoming, Gong Shuidi, Zheng Xiaolong, Shen Yingshan, Pang Fengxiang, Chen Lixin, Li Weifeng, Yang Fan, Liu Shaojun, He Wei, Wei Qiushi. Trends in global research on bone and joint tuberculosis: bibliometrics and visual analysis [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(20): 3234-3239.

Figures/Tables 4

2.2 骨与关节结核相关出版文献的多角度分析 2.2.1 全球骨与关节结核研究方向分析图2A显示了目前骨与关节结核的主要研究方向，目前研究最集中在免疫学这一领域，其他的主要方向为：骨科学、传染病学、微生物学及内科学。 2.2.2 研究骨与关节结核的主要机构分析在医学领域进行科学研究需要良好的研究平台。学者进行科学研究需借助科研机构的帮助。图2B显示了1994至2018年全球有关骨与关节结核的文献发表量排在前20的机构，其中Central South University发表46篇文献，在诸多机构中排名第一；The University of Cape Town发表43篇，位列第二；University College London位列第三，其文献发表量为38篇。 2.2.3 研究骨与关节结核的主要学者分析图2C为在骨与关节结核领域发表文献排在全球前20的作者分布。1994至2018年全球共发表2 761篇有关骨与关节结核的英文文献，而发表量在前20的学者所发表的文献数量为244篇，占总发表量的8.837%，其中ZHANG HQ、SINGH S、WANG XY三位学者排名前三，分别发表了17，15，14篇文献。 2.2.4 支持骨与关节结核研究的主要基金分析图2D列出支持骨与关节结核研究产出文献前20的基金项目。NIAID NIH HHS排名第一，共支持产出发表76篇有关骨与关节结核的文献；中国国家自然科学基金会位列第二，共支持产出51篇文献；NATIONAL INSTITUTES OF HEALTH排名第三，支持产出42文献。 2.2.5 刊登骨与关节结核文献的期刊杂志分析目前国际上常用的既能评价文献质量又能衡量期刊杂志水平的一项指标是影响因子。图2E显示1994至2018年收录并公开刊登骨与关节结核相关文献排名前20的期刊杂志，发表最多文献的杂志是《PLOS ONE》，共67篇(该杂志 2017年影响因子2.766)，其H指数为19，被引总频次为1 090；其次是《JOURNAL OF IMMUNOLOGY》，共刊登62篇文献(该杂志 2017年影响因子4.539)，其H指数为35，被引总频次为3 896；《NFECTION AND IMMUNITY》刊登54篇文献(该杂志 2017年影响因子3.256)，H指数为29，被引总频次为2 395。 "

2.3 有关骨与关节结核文献的可视化分析共现分析：在文献计量学中共现是指多篇论文之间共同出现的关键词、共同出现的作者、共同出现的机构等，共现分析是对共同出现的现象的定量研究，以揭示信息的内容关联和特征项所隐含的知识，能帮助发现当前研究的方向及研究热点，对科学研究的发展具有一定的引导作用[12]。骨与关节结核的研究方向分析：应用Vos viewer软件的共现分析功能，共有9 595个关键词，共同出现次数在5次以上为纳入标准，共纳入884个关键词(如图3A所示)。可将目前全球有关骨与关节结核的研究分为6大类：结核病的诊断与治疗、脊柱结核的治疗与并发症、骨与关节结核的发病特点、分子生物学检测、细胞学研究、免疫学研究。将6大类研究方向进一步细化分析，可知在结核病的诊断与治疗中，结核杆菌、感染、危险因素、诊断、肺外结核是最常出现的5个关键词。在脊柱结核的治疗与并发症中，常出现的关键词有：融合、手术、驼背、畸形、清创。在骨与关节结核的发病特点中，儿童、脊髓炎、关节炎、化脓、磁共振出现的次数较多。在分子生物学检测中，常出现的关键词有：确诊、PCR、DNA、病理、流行病学。在细胞学研究中，常出现的关键词有：结核分歧杆菌、T细胞、树突细胞、肿瘤坏死因子、伽玛干扰素。在免疫学研究中，免疫反应、危险、敏感性、多态性、维生素D最常出现。骨与关节结核研究的发展趋势分析：通过Vos viewer软件的发展趋势分析功能，整理从1994至2018年的热点研究方向，并归纳出重要时间段出现频率较高的关键词。如图3B所示，随着时间的推移，有关骨与关节结核的研究方向发生变化，图中右下角有一颜色从蓝-浅蓝-绿-黄-橙-红排列的刻度线，蓝色部分表示关键词出现的时间较早，属于较早期的研究热点，随着时间的推移，红色部分代表当前的研究热点。图3B蓝色部分表示有关骨与关节结核的研究长期集中在细胞学水平上的研究以及结核分歧杆菌的特点上，较少出现新的研究方向。图3B红色部分表示GeneXpert MTB/RIF检测是目前较新的研究方向，提示这个方向有可能是骨与关节结核的研究热点。 "

References

[1] 秦世炳,董伟杰,周新华,等.正确理解和认识骨与关节结核诊疗的若干问题[J].中国防痨杂志,2013,35(5):384-392.
[2] 岳跃兵,沈杰.腕关节结核误诊为痛风1例[J].广东医学,2016,37(20): 3156.
[3] 马远征,胡明,才晓军,等.脊柱结核外科治疗的探讨[J].中华骨科杂志, 2005, 25(2):68-73.
[4] 张军,丁晶.膝关节结核的诊断与治疗[J].中国骨与关节损伤杂志, 2015,30(12):1342-1344.
[5] 秦世炳.重视结核病诊治和脊柱结核手术时机的选择[J].中国骨伤, 2013,26(7):533-535.
[6] PU QH, LYU QJ, SU HY.Bibliometric analysis of scientific publications in transplantation journals from Mainland China, Japan, South Korea and Taiwan between 2006 and 2015.BMJ Open.2016;6(8):e011623.
[7] XING D, ZHAO Y, DONG SJ, et al.Global research trends in stem cells for osteoarthritis: a bibliometric and visualized study.Int J Rheum Dis. 2018;21(7): 1372-1384.
[8] JIA ZW, WU YH, LI H, et al.Growing trend of China's contribution to the field of spine: a 10-year survey of the literature.Eur Spine J. 2015;24(8): 1806-1812.
[9] ZHANG K, ZHAO J, CHU L, et al.China’s growing contribution to sepsis research from 1984 to 2014: A bibliometric study.Medicine. 2017;96(25):e7275.
[10] BORNMANN L,DANIEL HD.The state of h index research. Is the h index the ideal way to measure research performance?Embo Rep. 2009;10(1):2-6.
[11] GAO Y, WANG Y, ZHAI X, et al.Publication trends of research on diabetes mellitus and T cells (1997-2016):A 20-year bibliometric study. PLoS One.2017;12(9):e184869.
[12] 张宏梁,田玲,马凌飞,等.从论文合著看医学研究的合作[J].生命科学, 2010,23(12): 1281-1287.
[13] LUO X, LIANG Z, GONG F, et al.Worldwide productivity in the field of foot and ankle research from 2009e2013: a bibliometric analysis of highly cited journals. J Foot Ankle Res.2015;8(12):1-6.
[14] BRODERICK C, HOPKINS S, MACK DJF, et al.Delays in the diagnosis and treatment of bone and joint tuberculosis in the United Kingdom.Bone Joint J.2018;100-B(1):119-124.
[15] ZHANG Q, ZHANG Q, SUN BQ, et al.GeneXpert MTB/RIF for rapid diagnosis and rifampin resistance detection of endobronchial tuberculosis. Respirology.2018;23(10):950-955.
[16] 赵金云,金发祥,许文芳,等.应用GeneXpert MTB/RIF对多耐药MTB及RIF耐药性的快速检测[J].中华医院感染学杂志,2017,27(19): 4340-4343.
[17] LI Y, JIA WY, LEI GH, et al.Diagnostic efficiency of Xpert MTB/RIF assay for osteoarticular tuberculosis in patients with inflammatory arthritis in China. PLoS One.2018;13(6):e0198600.
[18] SCOTT C, WALUSIMBI S, KIRENGA B, et al. Evaluation of Automated Molecular Testing Rollout for Tuberculosis Diagnosis Using Routinely Collected Surveillance Data - Uganda, 2012-2015. MMWR Morb Mortal Wkly Rep.2017;66(12):339-342.
[19] NGWIRA L G, CORBETT EL, KHUNDI M, et al.Screening for tuberculosis with Xpert MTB/RIF versus fluorescent microscopy among adults newly diagnosed with HIV in rural Malawi: a cluster randomized trial (CHEPETSA).Clin Infect Dis.2019;68(7): 1176-1183.
[20] WANG GR, DONG WJ, LAN TL, et al.Diagnostic accuracy evaluation of the conventional and molecular tests for Spinal Tuberculosis in a cohort, head-to-head study. Emerg Microbes Infect.2018; 7(1): 109.